ENSG00000103319


Homo sapiens

Features
Gene ID: ENSG00000103319
  
Biological name :EEF2K
  
Synonyms : EEF2K / eukaryotic elongation factor 2 kinase / O00418
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p12.2
Gene start: 22206282
Gene end: 22288732
  
Corresponding Affymetrix probe sets: 225545_at (Human Genome U133 Plus 2.0 Array)   225546_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263026
Ensembl peptide - ENSP00000456243
NCBI entrez gene - 29904     See in Manteia.
OMIM - 606968
RefSeq - XM_017023194
RefSeq - NM_013302
RefSeq - XM_017023193
RefSeq Peptide - NP_037434
swissprot - O00418
swissprot - H3BRH4
Ensembl - ENSG00000103319
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eef2kENSDARG00000035835Danio rerio
 EEF2KENSGALG00000006982Gallus gallus
 Eef2kENSMUSG00000035064Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALPK1 / Q96QP1 / alpha kinase 1ENSG0000007333115


Protein motifs (from Interpro)
Interpro ID Name
 IPR004166  MHCK/EF2 kinase
 IPR006597  Sel1-like repeat
 IPR011009  Protein kinase-like domain superfamily
 IPR017400  Eukaryotic elongation factor 2 kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006414 translational elongation TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031952 regulation of protein autophosphorylation IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071454 cellular response to anoxia IEA
 biological_processGO:1990416 cellular response to brain-derived neurotrophic factor stimulus IEA
 biological_processGO:1990637 response to prolactin IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004686 elongation factor-2 kinase activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005516 calmodulin binding IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008135 translation factor activity, RNA binding TAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
mTORC1-mediated signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108443 P23443 / RPS6KB1 / ribosomal protein S6 kinase B1  / reaction






 

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