Manteia

ENSG00000134001

Homo sapiens

Features

Gene ID:	ENSG00000134001

Biological name :	EIF2S1

Synonyms :	EIF2S1 / eukaryotic translation initiation factor 2 subunit alpha / P05198

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	14
Strand:	1
Band:	q23.3
Gene start:	67359997
Gene end:	67386516

Corresponding Affymetrix probe sets:	201142_at (Human Genome U133 Plus 2.0 Array) 201143_s_at (Human Genome U133 Plus 2.0 Array) 201144_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000256383 Ensembl peptide - ENSP00000425299 Ensembl peptide - ENSP00000451975 Ensembl peptide - ENSP00000452034 NCBI entrez gene - 1965 See in Manteia. OMIM - 603907 RefSeq - NM_004094 RefSeq Peptide - NP_004085 swissprot - Q53XC0 swissprot - G3V4T5 swissprot - H0YJS4 swissprot - P05198 Ensembl - ENSG00000134001

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
eif2s1a	ENSDARG00000005827	Danio rerio
eif2s1b	ENSDARG00000052178	Danio rerio
EIF2S1	ENSGALG00000009565	Gallus gallus
Eif2s1	ENSMUSG00000021116	Mus musculus

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR003029	S1 domain
IPR011488	Translation initiation factor 2, alpha subunit
IPR012340	Nucleic acid-binding, OB-fold
IPR022967	RNA-binding domain, S1
IPR024054	Translation initiation factor 2, alpha subunit, middle domain superfamily
IPR024055	Translation initiation factor 2, alpha subunit, C-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006412	translation	IEA
biological_process	GO:0006413	translational initiation	IEA
biological_process	GO:0006417	regulation of translation	IEA
biological_process	GO:0007568	aging	IEA
biological_process	GO:0032057	negative regulation of translational initiation in response to stress	ISS
biological_process	GO:0034198	cellular response to amino acid starvation	ISS
biological_process	GO:0034605	cellular response to heat	IEA
biological_process	GO:0034644	cellular response to UV	ISS
biological_process	GO:0034976	response to endoplasmic reticulum stress	IMP
biological_process	GO:0036499	PERK-mediated unfolded protein response	TAS
biological_process	GO:0043558	regulation of translational initiation in response to stress	IEA
biological_process	GO:0046777	protein autophosphorylation	IEA
biological_process	GO:0055085	transmembrane transport	TAS
biological_process	GO:1901216	positive regulation of neuron death	IMP
biological_process	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity	IEA
biological_process	GO:1990737	response to manganese-induced endoplasmic reticulum stress	IEA
biological_process	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005840	ribosome	IBA
cellular_component	GO:0005844	polysome	TAS
cellular_component	GO:0005850	eukaryotic translation initiation factor 2 complex	IDA
cellular_component	GO:0005851	eukaryotic translation initiation factor 2B complex	IDA
cellular_component	GO:0010494	cytoplasmic stress granule	ISS
cellular_component	GO:0016020	membrane	HDA
cellular_component	GO:0033290	eukaryotic 48S preinitiation complex	IBA
cellular_component	GO:0043614	multi-eIF complex	IBA
cellular_component	GO:0044207	translation initiation ternary complex	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:0097451	glial limiting end-foot	IEA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003723	RNA binding	IEA
molecular_function	GO:0003743	translation initiation factor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0043022	ribosome binding	IDA

Pathways (from Reactome)

Pathway description

L13a-mediated translational silencing of Ceruloplasmin expression

PERK regulates gene expression

ABC-family proteins mediated transport

Translation initiation complex formation

Formation of the ternary complex, and subsequently, the 43S complex

Ribosomal scanning and start codon recognition

GTP hydrolysis and joining of the 60S ribosomal subunit

Recycling of eIF2:GDP

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000130741	EIF2S3 / P41091 / eukaryotic translation initiation factor 2 subunit gamma	/ complex
ENSG00000204574	ABCF1 / Q8NE71 / ATP binding cassette subfamily F member 1	/ complex / reaction
ENSG00000070756	P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1	/ reaction
ENSG00000156976	EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2	/ reaction
ENSG00000161960	EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1	/ reaction
ENSG00000106682	EIF4H / Q15056 / eukaryotic translation initiation factor 4H	/ reaction
ENSG00000151247	EIF4E / P06730 / eukaryotic translation initiation factor 4E	/ reaction
ENSG00000114867	EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1	/ reaction
ENSG00000063046	EIF4B / P23588 / eukaryotic translation initiation factor 4B	/ reaction
ENSG00000125977	EIF2S2 / P20042 / eukaryotic translation initiation factor 2 subunit beta	/ complex
ENSG00000172071	Q9NZJ5 / EIF2AK3 / eukaryotic translation initiation factor 2 alpha kinase 3	/ reaction
ENSG00000173674	EIF1AX / P47813 / eukaryotic translation initiation factor 1A, X-linked	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr