ENSG00000106682


Homo sapiens

Features
Gene ID: ENSG00000106682
  
Biological name :EIF4H
  
Synonyms : EIF4H / eukaryotic translation initiation factor 4H / Q15056
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q11.23
Gene start: 74174245
Gene end: 74197101
  
Corresponding Affymetrix probe sets: 206621_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265753
Ensembl peptide - ENSP00000265754
NCBI entrez gene - 7458     See in Manteia.
OMIM - 603431
RefSeq - XM_011516557
RefSeq - NM_022170
RefSeq - NM_031992
RefSeq - XM_011516556
RefSeq Peptide - NP_071496
RefSeq Peptide - NP_114381
swissprot - Q15056
Ensembl - ENSG00000106682
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4hENSDARG00000042252Danio rerio
 EIF4HENSGALG00000001313Gallus gallus
 Eif4hENSMUSG00000040731Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4B / P23588 / eukaryotic translation initiation factor 4BENSG0000006304642


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034229  eIF4H, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001731 formation of translation preinitiation complex IBA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0006446 regulation of translational initiation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019953 sexual reproduction IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0097010 eukaryotic translation initiation factor 4F complex assembly IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005844 polysome IBA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003743 translation initiation factor activity TAS
 molecular_functionGO:0004386 helicase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008135 translation factor activity, RNA binding TAS
 molecular_functionGO:0033592 RNA strand annealing activity IBA
 molecular_functionGO:0034057 RNA strand-exchange activity IBA
 molecular_functionGO:0043024 ribosomal small subunit binding IBA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130741 EIF2S3 / P41091 / eukaryotic translation initiation factor 2 subunit gamma  / reaction
 ENSG00000134001 EIF2S1 / P05198 / eukaryotic translation initiation factor 2 subunit alpha  / reaction
 ENSG00000063046 EIF4B / P23588 / eukaryotic translation initiation factor 4B  / complex
 ENSG00000173674 EIF1AX / P47813 / eukaryotic translation initiation factor 1A, X-linked  / reaction
 ENSG00000125977 EIF2S2 / P20042 / eukaryotic translation initiation factor 2 subunit beta  / reaction
 ENSG00000070756 P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / complex
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / complex
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / complex
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / complex






 

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