ENSMUSG00000040731


Mus musculus

Features
Gene ID: ENSMUSG00000040731
  
Biological name :Eif4h
  
Synonyms : Eif4h / Eukaryotic translation initiation factor 4H / Q9WUK2
  
Possible biological names infered from orthology : Q15056
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 134619721
Gene end: 134639490
  
Corresponding Affymetrix probe sets: 10534316 (MoGene1.0st)   1416941_s_at (Mouse Genome 430 2.0 Array)   1438554_x_at (Mouse Genome 430 2.0 Array)   1442942_at (Mouse Genome 430 2.0 Array)   1445746_at (Mouse Genome 430 2.0 Array)   1447070_at (Mouse Genome 430 2.0 Array)   1451521_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048833
Ensembl peptide - ENSMUSP00000143910
NCBI entrez gene - 22384     See in Manteia.
MGI - MGI:1341822
RefSeq - NM_033561
RefSeq - NM_001312867
RefSeq Peptide - NP_001299796
RefSeq Peptide - NP_291039
swissprot - Q3TG58
swissprot - Q564E5
swissprot - Q9WUK2
Ensembl - ENSMUSG00000040731
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4hENSDARG00000042252Danio rerio
 EIF4HENSGALG00000001313Gallus gallus
 EIF4HENSG00000106682Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif4b / Q8BGD9 / Eukaryotic translation initiation factor 4B / P23588*ENSMUSG0000005865544


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034229  eIF4H, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001731 formation of translation preinitiation complex IBA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0019953 sexual reproduction IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0097010 eukaryotic translation initiation factor 4F complex assembly IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005844 polysome IBA
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IBA
 molecular_functionGO:0033592 RNA strand annealing activity IBA
 molecular_functionGO:0034057 RNA strand-exchange activity IBA
 molecular_functionGO:0043024 ribosomal small subunit binding IBA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Ribosomal scanning and start codon recognition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0008526 decreased skull width "having a decreased side-to-side distance of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

 MP:0010031 abnormal cranium size "deviation from the average range of cranium size compared to normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1.1Jwhe/Grin2btm1.1Jwhe
Genetic Background: B6JBomTac.129P2-Grin2btm1.1Jwhe

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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