ENSDARG00000005827


Danio rerio

Features
Gene ID: ENSDARG00000005827
  
Biological name :eif2s1a
  
Synonyms : eif2s1a / eukaryotic translation initiation factor 2, subunit 1 alpha a
  
Possible biological names infered from orthology : EIF2S1 / Eukaryotic translation initiation factor 2 subunit 1 / eukaryotic translation initiation factor 2 subunit alpha / P05198 / Q6ZWX6
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 34244345
Gene end: 34254233
  
Corresponding Affymetrix probe sets: Dr.24582.1.S1_at (Zebrafish Array)   NM_199569_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000026560
NCBI entrez gene - 321807     See in Manteia.
RefSeq - NM_199569
RefSeq Peptide - NP_955863
swissprot - Q7ZWD3
ZFIN ID - ZDB-GENE-030131-526
Ensembl - ENSDARG00000005827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EIF2S1ENSGALG00000009565Gallus gallus
 EIF2S1ENSG00000134001Homo sapiens
 Eif2s1ENSMUSG00000021116Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eif2s1b / eukaryotic translation initiation factor 2, subunit 1 alpha b / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...ENSDARG0000005217896


Protein motifs (from Interpro)
Interpro ID Name
 IPR003029  S1 domain
 IPR011488  Translation initiation factor 2, alpha subunit
 IPR012340  Nucleic acid-binding, OB-fold
 IPR022967  RNA-binding domain, S1
 IPR024054  Translation initiation factor 2, alpha subunit, middle domain superfamily
 IPR024055  Translation initiation factor 2, alpha subunit, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006413 translational initiation IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005840 ribosome IBA
 cellular_componentGO:0005850 eukaryotic translation initiation factor 2 complex IBA
 cellular_componentGO:0005851 eukaryotic translation initiation factor 2B complex IBA
 cellular_componentGO:0033290 eukaryotic 48S preinitiation complex IBA
 cellular_componentGO:0043614 multi-eIF complex IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IBA
 molecular_functionGO:0043022 ribosome binding IBA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
PERK regulates gene expression
ABC-family proteins mediated transport
Translation initiation complex formation
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Recycling of eIF2:GDP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000042252 eif4h / eukaryotic translation initiation factor 4h / Q15056* / Q9WUK2*  / reaction
 ENSDARG00000092115 eif4a1a / eukaryotic translation initiation factor 4A1A / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*  / reaction
 ENSDARG00000016477 eif4a2 / eukaryotic translation initiation factor 4A, isoform 2 / P10630* / Q14240* / eukaryotic translation initiation factor 4A2* / Mus musculus eukaryotic translation initiation factor 4...  / reaction
 ENSDARG00000003032 eif4a1b / eukaryotic translation initiation factor 4A1B / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*  / reaction
 ENSDARG00000008292 eif2s3 / F1QGW6 / eukaryotic translation initiation factor 2, subunit 3 gamma / Q9Z0N2* / P41091* / Q2VIR3* / Q9Z0N1* / EIF2S3B* / Eif2s3x* / Eif2s3y* / eukaryotic translation initiation fa...  / complex
 ENSDARG00000017219 pabpc1a / poly(A) binding protein, cytoplasmic 1a / PABPC1* / Pabpc2* / PABPC3* / Pabpc6* / Q9H361* / P11940* / P29341* / Polyadenylate-binding protein 1 * / poly(A) binding protein cytopla...  / reaction
 ENSDARG00000021140 pabpc1b / poly A binding protein, cytoplasmic 1 b / PABPC1* / Pabpc2* / PABPC3* / Pabpc6* / Q9H361* / P11940* / P29341* / Polyadenylate-binding protein 1 * / poly(A) binding protein cytopla...  / reaction
 ENSDARG00000062139 eif2ak3 / eukaryotic translation initiation factor 2-alpha kinase 3 / Q9NZJ5*  / reaction
 ENSDARG00000057912 eif1axb / eukaryotic translation initiation factor 1A, X-linked, b / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction / complex
 ENSDARG00000029003 eif1axa / eukaryotic translation initiation factor 1A, X-linked, a / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / complex / reaction






 

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