ENSMUSG00000020715


Mus musculus

Features
Gene ID: ENSMUSG00000020715
  
Biological name :Ern1
  
Synonyms : Ern1 / Q9EQY0 / Serine/threonine-protein kinase/endoribonuclease IRE1 Serine/threonine-protein kinase Endoribonuclease
  
Possible biological names infered from orthology : endoplasmic reticulum to nucleus signaling 1 / O75460
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 106394650
Gene end: 106487852
  
Corresponding Affymetrix probe sets: 10392183 (MoGene1.0st)   1421240_at (Mouse Genome 430 2.0 Array)   1431886_at (Mouse Genome 430 2.0 Array)   1437119_at (Mouse Genome 430 2.0 Array)   1438583_at (Mouse Genome 430 2.0 Array)   1450176_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102411
Ensembl peptide - ENSMUSP00000102413
Ensembl peptide - ENSMUSP00000102412
Ensembl peptide - ENSMUSP00000001059
NCBI entrez gene - 78943     See in Manteia.
MGI - MGI:1930134
RefSeq - NM_023913
RefSeq Peptide - NP_076402
swissprot - B1ARJ5
swissprot - B1ATQ7
swissprot - Q3TBZ5
swissprot - Q9EQY0
Ensembl - ENSMUSG00000020715
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ern1ENSDARG00000013997Danio rerio
 ERN1ENSGALG00000003476Gallus gallus
 ERN1ENSG00000178607Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ern2 / Q9Z2E3 / Serine/threonine-protein kinase/endoribonuclease IRE2 Serine/threonine-protein kinase Endoribonuclease / Q76MJ5* / endoplasmic reticulum to nucleus signaling 2*ENSMUSG0000003086645


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR010513  KEN domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR018391  Pyrrolo-quinoline quinone beta-propeller repeat
 IPR018997  PUB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001935 endothelial cell proliferation ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006379 mRNA cleavage ISO
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0006987 obsolete activation of signaling protein activity involved in unfolded protein response ISS
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007257 activation of JUN kinase activity IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IDA
 biological_processGO:0030969 obsolete mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response IEA
 biological_processGO:0033120 positive regulation of RNA splicing ISO
 biological_processGO:0034976 response to endoplasmic reticulum stress ISO
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus ISO
 biological_processGO:0036289 peptidyl-serine autophosphorylation ISO
 biological_processGO:0036498 IRE1-mediated unfolded protein response IDA
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation ISO
 biological_processGO:0070055 obsolete mRNA endonucleolytic cleavage involved in unfolded protein response IDA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0071333 cellular response to glucose stimulus ISO
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0098787 mRNA cleavage involved in mRNA processing IEA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response ISO
 biological_processGO:1901142 insulin metabolic process ISO
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation ISO
 biological_processGO:1990579 peptidyl-serine trans-autophosphorylation ISO
 cellular_componentGO:0005637 nuclear inner membrane IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane ISO
 cellular_componentGO:1990597 AIP1-IRE1 complex IPI
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex ISO
 cellular_componentGO:1990630 IRE1-RACK1-PP2A complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004519 endonuclease activity IDA
 molecular_functionGO:0004521 endoribonuclease activity ISO
 molecular_functionGO:0004540 ribonuclease activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0030544 Hsp70 protein binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043531 ADP binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding ISO


Pathways (from Reactome)
Pathway description
IRE1alpha activates chaperones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ern1tm1Dron/Ern1tm1Dron
Genetic Background: involves: 129S6/SvEvTac

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkntm2Tmd/Prkntm2Tmd
Genetic Background: Not Specified

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ern1tm2.1Tiw/Ern1tm2.1Tiw,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ern1tm1Dron/Ern1tm1Dron
Genetic Background: involves: 129S6/SvEvTac

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004264 abnormal extraembryonic tissue physiology "functional anomaly of the membranes involved with embryonic protection and nutrition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004265 abnormal placental transport "anomaly in the conveyance of metabolic products and nutrients across the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0010331 abnormal apolipoprotein level "anomaly in the amount of the a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ern1tm1Dron/Ern1tm1Dron
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020715 Ern1 / Q9EQY0 / Serine/threonine-protein kinase/endoribonuclease IRE1 Serine/threonine-protein kinase Endoribonuclease / O75460* / endoplasmic reticulum to nucleus signaling 1*  / complex / reaction
 ENSMUSG00000026864 Hspa5 / P20029 / heat shock protein 5 / P11021* / heat shock protein family A (Hsp70) member 5*  / complex






 

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