ENSMUSG00000030866


Mus musculus

Features
Gene ID: ENSMUSG00000030866
  
Biological name :Ern2
  
Synonyms : Ern2 / Q9Z2E3 / Serine/threonine-protein kinase/endoribonuclease IRE2 Serine/threonine-protein kinase Endoribonuclease
  
Possible biological names infered from orthology : endoplasmic reticulum to nucleus signaling 2 / Q76MJ5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F2
Gene start: 122169893
Gene end: 122186207
  
Corresponding Affymetrix probe sets: 10567680 (MoGene1.0st)   1450139_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033153
Ensembl peptide - ENSMUSP00000145716
NCBI entrez gene - 26918     See in Manteia.
MGI - MGI:1349436
RefSeq - XM_017322282
RefSeq - NM_001316689
RefSeq - NM_012016
RefSeq - XM_011241820
RefSeq - XM_011241821
RefSeq - XM_011241822
RefSeq - XM_011241823
RefSeq - XM_011241817
RefSeq - XM_011241818
RefSeq - XM_011241819
RefSeq Peptide - NP_036146
RefSeq Peptide - NP_001303618
swissprot - Q3UTN5
swissprot - Q9Z2E3
Ensembl - ENSMUSG00000030866
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ern2ENSDARG00000058475Danio rerio
 ERN2ENSGALG00000027592Gallus gallus
 ERN2ENSG00000134398Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ern1 / Q9EQY0 / Serine/threonine-protein kinase/endoribonuclease IRE1 Serine/threonine-protein kinase Endoribonuclease / O75460* / endoplasmic reticulum to nucleus signaling 1*ENSMUSG0000002071549


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR010513  KEN domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR018391  Pyrrolo-quinoline quinone beta-propeller repeat
 IPR018997  PUB domain
 IPR033523  Serine/threonine-protein kinase/endoribonuclease IRE2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0006987 obsolete activation of signaling protein activity involved in unfolded protein response ISS
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016075 rRNA catabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030263 apoptotic chromosome condensation IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004540 ribonuclease activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ern2m1Btlr/Ern2m1Btlr
Genetic Background: C57BL/6J-Ern2m1Btlr

Allelic Composition: Ern2M2Btlr/Ern2M2Btlr
Genetic Background: C57BL/6J-Ern2M2Btlr

Allelic Composition: Ern2m3Btlr/Ern2m3Btlr
Genetic Background: C57BL/6J-Ern2m3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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