ENSG00000134398


Homo sapiens

Features
Gene ID: ENSG00000134398
  
Biological name :ERN2
  
Synonyms : endoplasmic reticulum to nucleus signaling 2 / ERN2 / Q76MJ5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p12.2
Gene start: 23690326
Gene end: 23713500
  
Corresponding Affymetrix probe sets: 214372_x_at (Human Genome U133 Plus 2.0 Array)   223910_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000256797
Ensembl peptide - ENSP00000456866
Ensembl peptide - ENSP00000457361
Ensembl peptide - ENSP00000457796
Ensembl peptide - ENSP00000413812
NCBI entrez gene - 10595     See in Manteia.
OMIM - 604034
RefSeq - XM_011545713
RefSeq - NM_001308220
RefSeq - NM_033266
RefSeq - XM_011545708
RefSeq - XM_011545709
RefSeq - XM_011545711
RefSeq - XM_011545712
RefSeq Peptide - NP_150296
RefSeq Peptide - NP_001295149
swissprot - H3BTW8
swissprot - Q76MJ5
swissprot - E7ETG2
swissprot - H3BUU2
swissprot - H3BSU1
Ensembl - ENSG00000134398
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ern2ENSDARG00000058475Danio rerio
 ERN2ENSGALG00000027592Gallus gallus
 Ern2ENSMUSG00000030866Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERN1 / O75460 / endoplasmic reticulum to nucleus signaling 1ENSG0000017860751


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR010513  KEN domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR018391  Pyrrolo-quinoline quinone beta-propeller repeat
 IPR018997  PUB domain
 IPR033523  Serine/threonine-protein kinase/endoribonuclease IRE2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016075 rRNA catabolic process IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030263 apoptotic chromosome condensation IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004519 endonuclease activity IDA
 molecular_functionGO:0004540 ribonuclease activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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