ENSG00000178607


Homo sapiens

Features
Gene ID: ENSG00000178607
  
Biological name :ERN1
  
Synonyms : endoplasmic reticulum to nucleus signaling 1 / ERN1 / O75460
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q23.3
Gene start: 64039142
Gene end: 64130819
  
Corresponding Affymetrix probe sets: 207061_at (Human Genome U133 Plus 2.0 Array)   227755_at (Human Genome U133 Plus 2.0 Array)   235745_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401445
Ensembl peptide - ENSP00000475519
NCBI entrez gene - 2081     See in Manteia.
OMIM - 604033
RefSeq - XM_017024348
RefSeq - NM_001433
RefSeq - XM_017024347
RefSeq Peptide - NP_001424
swissprot - O75460
Ensembl - ENSG00000178607
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ern1ENSDARG00000013997Danio rerio
 ERN1ENSGALG00000003476Gallus gallus
 Ern1ENSMUSG00000020715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERN2 / Q76MJ5 / endoplasmic reticulum to nucleus signaling 2ENSG0000013439848


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR010513  KEN domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR018391  Pyrrolo-quinoline quinone beta-propeller repeat
 IPR018997  PUB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001935 endothelial cell proliferation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006402 mRNA catabolic process TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0006987 obsolete activation of signaling protein activity involved in unfolded protein response IDA
 biological_processGO:0007050 cell cycle arrest ISS
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0030969 obsolete mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response IDA
 biological_processGO:0033120 positive regulation of RNA splicing IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IDA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IDA
 biological_processGO:0036498 IRE1-mediated unfolded protein response IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation IDA
 biological_processGO:0070055 obsolete mRNA endonucleolytic cleavage involved in unfolded protein response TAS
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0098787 mRNA cleavage involved in mRNA processing IDA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IMP
 biological_processGO:1901142 insulin metabolic process IDA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IMP
 biological_processGO:1990579 peptidyl-serine trans-autophosphorylation IMP
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:1990332 Ire1 complex NAS
 cellular_componentGO:1990597 AIP1-IRE1 complex IEA
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IDA
 cellular_componentGO:1990630 IRE1-RACK1-PP2A complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity TAS
 molecular_functionGO:0004540 ribonuclease activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030544 Hsp70 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IDA


Pathways (from Reactome)
Pathway description
IRE1alpha activates chaperones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000044574 HSPA5 / P11021 / heat shock protein family A (Hsp70) member 5  / complex
 ENSG00000178607 ERN1 / O75460 / endoplasmic reticulum to nucleus signaling 1  / reaction / complex






 

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