2081


Homo sapiens (NCBI)

Features
Gene ID: 2081
  
Biological name :
  
Synonyms : endoplasmic reticulum to nucleus signaling 1 / ERN1 / IRE1|IRE1P|IRE1a|hIRE1p
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 207061_at (Human Genome U133 Plus 2.0 Array)   235745_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034598735
RefSeq - 1034598737
RefSeq - 153946421
RefSeq - NC_000017.11
RefSeq - NP_001424.3
RefSeq - XP_016879836.1
RefSeq - XP_016879837.1
RefSeq - XM_017024347.2
RefSeq - NM_001433.4
RefSeq - NM_152461.2
RefSeq - XM_017024348.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000178607 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001935 endothelial cell proliferation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006379 mRNA cleavage ISS
 biological_processGO:0006402 mRNA catabolic process TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007050 cell cycle arrest ISS
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0033120 positive regulation of RNA splicing IDA
 biological_processGO:0034620 cellular response to unfolded protein IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IDA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IDA
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation TAS
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0098787 mRNA cleavage involved in mRNA processing IDA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IMP
 biological_processGO:1901142 insulin metabolic process IDA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IMP
 biological_processGO:1990579 peptidyl-serine trans-autophosphorylation IMP
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:1990332 Ire1 complex NAS
 cellular_componentGO:1990597 AIP1-IRE1 complex IEA
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IDA
 cellular_componentGO:1990630 IRE1-RACK1-PP2A complex IDA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004521 endoribonuclease activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030544 Hsp70 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0051879 Hsp90 protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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