ENSGALG00000003476


Gallus gallus

Features
Gene ID: ENSGALG00000003476
  
Biological name :ERN1
  
Synonyms : endoplasmic reticulum to nucleus signaling 1 / ERN1
  
Possible biological names infered from orthology : O75460 / Q9EQY0 / Serine/threonine-protein kinase/endoribonuclease IRE1 Serine/threonine-protein kinase Endoribonuclease
  
Species: Gallus gallus
  
Chr. number: 18
Strand: -1
Band:
Gene start: 6829425
Gene end: 6861860
  
Corresponding Affymetrix probe sets: Gga.10887.1.S1_at (Chicken Array)   Gga.10887.1.S1_s_at (Chicken Array)   Gga.16133.1.S1_at (Chicken Array)   GgaAffx.25872.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005493
NCBI entrez gene - 417414     See in Manteia.
RefSeq - NM_001285499
RefSeq - XM_015279888
RefSeq - XM_015279890
RefSeq Peptide - NP_001272428
swissprot - F1NPU5
Ensembl - ENSGALG00000003476
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ern1ENSDARG00000013997Danio rerio
 ERN1ENSG00000178607Homo sapiens
 Ern1ENSMUSG00000020715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERN2 / serine/threonine-protein kinase/endoribonuclease IRE2 precursor / Q76MJ5* / Q9Z2E3* / endoplasmic reticulum to nucleus signaling 2* / Serine/threonine-protein kinase/endoribonucleas...ENSGALG0000002759255


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR010513  KEN domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR018391  Pyrrolo-quinoline quinone beta-propeller repeat
 IPR018997  PUB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006987 obsolete activation of signaling protein activity involved in unfolded protein response IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0030969 obsolete mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response IEA
 biological_processGO:0033120 positive regulation of RNA splicing IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IEA
 biological_processGO:0036498 IRE1-mediated unfolded protein response IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation IEA
 biological_processGO:0070055 obsolete mRNA endonucleolytic cleavage involved in unfolded protein response IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0098787 mRNA cleavage involved in mRNA processing IEA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IEA
 biological_processGO:1901142 insulin metabolic process IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1990579 peptidyl-serine trans-autophosphorylation IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 cellular_componentGO:1990597 AIP1-IRE1 complex IEA
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IEA
 cellular_componentGO:1990630 IRE1-RACK1-PP2A complex IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IEA
 molecular_functionGO:0004540 ribonuclease activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA


Pathways (from Reactome)
Pathway description
IRE1alpha activates chaperones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001000 HSPA5 / Q90593 / 78 kDa glucose-regulated protein / P11021* / P20029* / heat shock protein 5* / heat shock protein family A (Hsp70) member 5*  / complex
 ENSGALG00000003476 ERN1 / endoplasmic reticulum to nucleus signaling 1 / O75460* / Q9EQY0* / Serine/threonine-protein kinase/endoribonuclease IRE1 Serine/threonine-protein kinase Endoribonuclease*  / reaction / complex






 

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