ENSMUSG00000024847


Mus musculus

Features
Gene ID: ENSMUSG00000024847
  
Biological name :Aip
  
Synonyms : AH receptor-interacting protein / Aip / O08915
  
Possible biological names infered from orthology : aryl hydrocarbon receptor interacting protein / O00170
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4114446
Gene end: 4125858
  
Corresponding Affymetrix probe sets: 10464603 (MoGene1.0st)   1423128_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025767
Ensembl peptide - ENSMUSP00000113807
Ensembl peptide - ENSMUSP00000114096
NCBI entrez gene - 11632     See in Manteia.
MGI - MGI:109622
RefSeq - XM_006531642
RefSeq - NM_001276284
RefSeq - NM_016666
RefSeq - XM_006531641
RefSeq Peptide - NP_057875
RefSeq Peptide - NP_001263213
swissprot - O08915
swissprot - D3YW40
Ensembl - ENSMUSG00000024847
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aipENSDARG00000104437Danio rerio
 AIPENSGALG00000040247Gallus gallus
 AIPENSG00000110711Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aipl1 / Q924K1 / Aryl-hydrocarbon-interacting protein-like 1 / Q9NZN9* / aryl hydrocarbon receptor interacting protein like 1*ENSMUSG0000004055448


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR031208  AH receptor-interacting protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006626 protein targeting to mitochondrion ISO
 biological_processGO:0006805 xenobiotic metabolic process IPI
 biological_processGO:0010738 regulation of protein kinase A signaling IEA
 biological_processGO:0022417 protein maturation by protein folding ISS
 biological_processGO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity IEA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0034751 aryl hydrocarbon receptor complex IDA
 molecular_functionGO:0003712 transcription coregulator activity IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding IPI
 molecular_functionGO:0036004 GAF domain binding ISO
 molecular_functionGO:0051082 unfolded protein binding ISO


Pathways (from Reactome)
Pathway description
Aryl hydrocarbon receptor signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rpe65tvrm148/Rpe65tvrm148
Genetic Background: C57BL/6J-Rpe65tvrm148/J

 MP:0001573 abnormal circulating alanine transaminase level "aberrent concentration in the blood of this enzyme, whcih transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: t+/th20,Itpr3tf/Itpr3tf
Genetic Background: involves: BTBR

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itm2btm1.1Ldad/Itm2btm1.1Ldad
Genetic Background: involves: 129

Allelic Composition: Aiptm1Bra/Aip+
Genetic Background: Not Specified

 MP:0003505 prolactinoma "a pituitary adenoma characterized by secretion of prolactin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: t+/th20,Itpr3tf/Itpr3tf
Genetic Background: involves: BTBR

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0004004 patent ductus venosus "failure of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein (that allows oxygenated blood to bypass the developing liver) to close in adults" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

Allelic Composition: Aiptm2Bra/Aiptm2Bra
Genetic Background: involves: 129/Sv

Allelic Composition: Aiptm2Bra/Aip+
Genetic Background: involves: 129/Sv

Allelic Composition: Aiptm1Bra/Aip+
Genetic Background: Not Specified

 MP:0008816 petechiae "very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0009078 adrenal gland hyperplasia "overdevelopment or increased size, usually due to a increased number of cells, of the endocrine glands located above the kidney and responsible for hormone and epinephrine secretion" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: t+/th20,Itpr3tf/Itpr3tf
Genetic Background: involves: BTBR

 MP:0010128 hypovolemia "an abnormally decreased amount of space occupied by blood in the vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Iduatm1.1Kmke/Iduatm1.1Kmke
Genetic Background: B6.129-Iduatm1.1Kmke

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019256 Ahr / aryl hydrocarbon receptor isoform 2 / P35869* / AC019117.3* / aryl hydrocarbon receptor*  / complex
 ENSMUSG00000071072 Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*  / complex
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr