ENSMUSG00000021575


Mus musculus

Features
Gene ID: ENSMUSG00000021575
  
Biological name :Ahrr
  
Synonyms : Ahrr / aryl-hydrocarbon receptor repressor
  
Possible biological names infered from orthology : A9YTQ3
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 74211118
Gene end: 74292331
  
Corresponding Affymetrix probe sets: 10410604 (MoGene1.0st)   1420796_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105268
Ensembl peptide - ENSMUSP00000022059
NCBI entrez gene - 11624     See in Manteia.
MGI - MGI:1333776
RefSeq - XM_006517050
RefSeq - NM_001317351
RefSeq - NM_009644
RefSeq - XM_006517048
RefSeq - XM_006517049
RefSeq Peptide - NP_033774
RefSeq Peptide - NP_001304280
swissprot - A0A0R4J1D3
swissprot - A0A0R4J020
Ensembl - ENSMUSG00000021575
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ahrrbENSDARG00000052618Danio rerio
 CABZ01114318.1ENSDARG00000099702Danio rerio
 AHRRENSGALG00000013402Gallus gallus
 AHRRENSG00000063438Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ahr / aryl hydrocarbon receptor isoform 2 / P35869* / AC019117.3* / aryl hydrocarbon receptor*ENSMUSG0000001925628


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Aryl hydrocarbon receptor signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0003382 straub tail "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015522 Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*  / complex / reaction
 ENSMUSG00000015709 Arnt2 / Q61324 / Aryl hydrocarbon receptor nuclear translocator 2 / Q9HBZ2*  / reaction / complex






 

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