ENSG00000100600


Homo sapiens

Features
Gene ID: ENSG00000100600
  
Biological name :LGMN
  
Synonyms : legumain / LGMN / Q99538
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.12
Gene start: 92703807
Gene end: 92748702
  
Corresponding Affymetrix probe sets: 201212_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452572
Ensembl peptide - ENSP00000451916
Ensembl peptide - ENSP00000452268
Ensembl peptide - ENSP00000334052
Ensembl peptide - ENSP00000376911
Ensembl peptide - ENSP00000450483
Ensembl peptide - ENSP00000450619
Ensembl peptide - ENSP00000450677
Ensembl peptide - ENSP00000450854
Ensembl peptide - ENSP00000451507
Ensembl peptide - ENSP00000451746
Ensembl peptide - ENSP00000451797
Ensembl peptide - ENSP00000451854
Ensembl peptide - ENSP00000451861
NCBI entrez gene - 5641     See in Manteia.
OMIM - 602620
RefSeq - XM_017021467
RefSeq - NM_001008530
RefSeq - NM_005606
RefSeq - XM_005267862
RefSeq - XM_005267863
RefSeq - XM_011536970
RefSeq - XM_017021463
RefSeq - XM_017021464
RefSeq - XM_017021465
RefSeq - XM_017021466
RefSeq Peptide - NP_001008530
RefSeq Peptide - NP_005597
swissprot - Q53XC6
swissprot - G3V2E9
swissprot - G3V2T4
swissprot - G3V3Z4
swissprot - G3V4E4
swissprot - G3V4P5
swissprot - G3V5B2
swissprot - H0YJN9
swissprot - Q99538
swissprot - G3V263
Ensembl - ENSG00000100600
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgmnENSDARG00000039150Danio rerio
 LGMNENSGALG00000010811Gallus gallus
 LgmnENSMUSG00000021190Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIGK / Q92643 / phosphatidylinositol glycan anchor biosynthesis class KENSG0000014289220


Protein motifs (from Interpro)
Interpro ID Name
 IPR001096  Peptidase C13, legumain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0003014 renal system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006624 vacuolar protein processing IBA
 biological_processGO:0010447 response to acidic pH IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0032801 receptor catabolic process IEA
 biological_processGO:0040015 negative regulation of multicellular organism growth IEA
 biological_processGO:0042359 vitamin D metabolic process TAS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:1901185 negative regulation of ERBB signaling pathway ISS
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0036021 endolysosome lumen TAS
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Vitamin D (calciferol) metabolism
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction






 

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contact: otassy@igbmc.fr