ENSG00000204257


Homo sapiens

Features
Gene ID: ENSG00000204257
  
Biological name :HLA-DMA
  
Synonyms : HLA-DMA / major histocompatibility complex, class II, DM alpha / P28067
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.32
Gene start: 32948613
Gene end: 32969094
  
Corresponding Affymetrix probe sets: 217478_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363976
Ensembl peptide - ENSP00000378714
Ensembl peptide - ENSP00000378716
Ensembl peptide - ENSP00000403122
Ensembl peptide - ENSP00000409668
NCBI entrez gene - 3108     See in Manteia.
OMIM - 142855
RefSeq - NM_006120
RefSeq Peptide - NP_006111
swissprot - Q6ICR9
swissprot - A2AAT8
swissprot - F6S093
swissprot - H0Y732
swissprot - P28067
swissprot - Q31604
swissprot - Q5SP00
Ensembl - ENSG00000204257
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MHCDMAENSGALG00000000158Gallus gallus
 H2-DMaENSMUSG00000037649Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1ENSG0000023138927
P06340 / HLA-DOA / major histocompatibility complex, class II, DO alphaENSG0000020425226
P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1ENSG0000019673526
P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2ENSG0000023754125
P01903 / HLA-DRA / major histocompatibility complex, class II, DR alphaENSG0000020428723


Protein motifs (from Interpro)
Interpro ID Name
 IPR001003  MHC class II, alpha chain, N-terminal
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR014745  MHC class II, alpha/beta chain, N-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002503 peptide antigen assembly with MHC class II protein complex IDA
 biological_processGO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0042613 MHC class II protein complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0023026 MHC class II protein complex binding IDA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204252 P06340 / HLA-DOA / major histocompatibility complex, class II, DO alpha  / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction / complex
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction / complex
 ENSG00000242574 P28068 / HLA-DMB / major histocompatibility complex, class II, DM beta  / complex
 ENSG00000241106 P13765 / HLA-DOB / major histocompatibility complex, class II, DO beta  / complex






 

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