ENSMUSG00000037649


Mus musculus

Features
Gene ID: ENSMUSG00000037649
  
Biological name :H2-DMa
  
Synonyms : H2-DMa / histocompatibility 2, class II, locus DMa
  
Possible biological names infered from orthology : HLA-DMA / major histocompatibility complex, class II, DM alpha / P28067
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34135182
Gene end: 34139101
  
Corresponding Affymetrix probe sets: 10444229 (MoGene1.0st)   1422527_at (Mouse Genome 430 2.0 Array)   1459872_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037088
NCBI entrez gene - 14998     See in Manteia.
MGI - MGI:95921
RefSeq - XM_017317260
RefSeq - NM_010386
RefSeq - XM_006523684
RefSeq Peptide - NP_034516
swissprot - Q31621
Ensembl - ENSMUSG00000037649
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MHCDMAENSGALG00000000158Gallus gallus
 P28067ENSG00000204257Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...ENSMUSG0000003659425
H2-Oa / major histocompatibility complex, class II, DO alpha / P06340* / HLA-DOA*ENSMUSG0000002433424


Protein motifs (from Interpro)
Interpro ID Name
 IPR001003  MHC class II, alpha chain, N-terminal
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR014745  MHC class II, alpha/beta chain, N-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002503 peptide antigen assembly with MHC class II protein complex IEA
 biological_processGO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042613 MHC class II protein complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0023026 MHC class II protein complex binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Cd74tm1Doi/Cd74tm1Doi,H2-DMatm1Doi/H2-DMatm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001835 abnormal antigen presentation "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: H2-DMatm1Luc/H2-DMatm1Luc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: H2-DMatm1Luc/H2-DMatm1Luc
Genetic Background: B6.129S4-H2-Dmatm1Luc

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Cd74tm1Doi/Cd74tm1Doi,H2-DMatm1Doi/H2-DMatm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-DMatm1Liz/H2-DMatm1Liz
Genetic Background: involves: BALB/cJ

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Cd74tm1Doi/Cd74tm1Doi,H2-DMatm1Doi/H2-DMatm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: H2-DMatm1Lkrl/H2-DMatm1Lkrl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: H2-DMatm1Liz/H2-DMatm1Liz
Genetic Background: involves: BALB/cJ

Allelic Composition: H2-DMatm2Liz/H2-DMatm2Liz
Genetic Background: involves: C57BL/6 * C57BL/10 * C57BR * CBA

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-DMatm1Luc/H2-DMatm1Luc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: H2-DMatm1Luc/H2-DMatm1Luc
Genetic Background: B6.129S4-H2-Dmatm1Luc

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: H2-DMatm1Lkrl/H2-DMatm1Lkrl
Genetic Background: involves: 129P2/OlaHsd

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Runx1tm1Dow/Runx1tm1Dow
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005041 abnormal antigen presentation via MHC class II "anomaly in the process by which peptide, bound to major histocomptability complex class II, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: H2-DMatm1Liz/H2-DMatm1Liz
Genetic Background: involves: BALB/cJ

Allelic Composition: H2-DMatm2Liz/H2-DMatm2Liz
Genetic Background: involves: C57BL/6 * C57BL/10 * C57BR * CBA

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74*)1Ayr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: H2-DMatm1Luc/H2-DMatm1Luc,Cd74tm1Doi/Cd74tm1Doi
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005043 defective assembly of class II molecules "impaired production of major histocompatibility complex class II molecules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-DMatm1Liz/H2-DMatm1Liz
Genetic Background: involves: BALB/cJ

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: H2-DMatm2Liz/H2-DMatm2Liz
Genetic Background: involves: C57BL/6 * C57BL/10 * C57BR * CBA

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: H2-DMatm1Lkrl/H2-DMatm1Lkrl
Genetic Background: involves: 129P2/OlaHsd

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: H2-DMatm1Luc/H2-DMatm1Luc
Genetic Background: B6.129S4-H2-Dmatm1Luc

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-DMatm1Luc/H2-DMatm1Luc
Genetic Background: B6.129S4-H2-Dmatm1Luc

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Cd74tm1Doi/Cd74tm1Doi,H2-DMatm1Doi/H2-DMatm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: H2-DMatm1Lkrl/H2-DMatm1Lkrl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Liz/H2-DMatm1Liz
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74*)1Ayr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd74tm1Doi/Cd74tm1Doi,H2-DMatm1Doi/H2-DMatm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / reaction / complex
 ENSMUSG00000037548 H2-DMb2 / histocompatibility 2, class II, locus Mb2 / P28068* / HLA-DMB* / AL645941.2* / major histocompatibility complex, class II, DM beta*  / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction / complex
 ENSMUSG00000024334 H2-Oa / major histocompatibility complex, class II, DO alpha / P06340* / HLA-DOA*  / complex
 ENSMUSG00000041538 H2-Ob / histocompatibility 2, O region beta locus / P13765* / HLA-DOB* / major histocompatibility complex, class II, DO beta*  / complex
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000079547 H2-DMb1 / histocompatibility 2, class II, locus Mb1 / P28068* / HLA-DMB* / AL645941.2* / major histocompatibility complex, class II, DM beta*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr