ENSMUSG00000024334


Mus musculus

Features
Gene ID: ENSMUSG00000024334
  
Biological name :H2-Oa
  
Synonyms : H2-Oa / major histocompatibility complex, class II, DO alpha
  
Possible biological names infered from orthology : HLA-DOA / P06340
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34092340
Gene end: 34095234
  
Corresponding Affymetrix probe sets: 10444223 (MoGene1.0st)   1419297_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025192
NCBI entrez gene - 15001     See in Manteia.
MGI - MGI:95924
RefSeq - NM_008206
RefSeq Peptide - NP_032232
swissprot - Q9QWV1
Ensembl - ENSMUSG00000024334
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CT583723.2ENSDARG00000116565Danio rerio
 CU914776.2ENSDARG00000114601Danio rerio
 si:busm1-194e12.11ENSDARG00000103716Danio rerio
 si:busm1-194e12.8ENSDARG00000103702Danio rerio
 si:busm1-266f07.2ENSDARG00000031745Danio rerio
 si:ch73-211l2.3ENSDARG00000075932Danio rerio
 si:zfos-2070c2.1ENSDARG00000070206Danio rerio
 si:zfos-367g9.1ENSDARG00000074816Danio rerio
 zgc:123107ENSDARG00000101675Danio rerio
 P06340ENSG00000204252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...ENSMUSG0000003659449
H2-DMa / histocompatibility 2, class II, locus DMa / P28067* / HLA-DMA* / major histocompatibility complex, class II, DM alpha*ENSMUSG0000003764925


Protein motifs (from Interpro)
Interpro ID Name
 IPR001003  MHC class II, alpha chain, N-terminal
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR014745  MHC class II, alpha/beta chain, N-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
 biological_processGO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0019882 antigen processing and presentation IMP
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
 biological_processGO:0045580 regulation of T cell differentiation IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042613 MHC class II protein complex ISO
 molecular_functionGO:0023026 MHC class II protein complex binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
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Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
Genetic Background: involves: CD-1

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0005041 abnormal antigen presentation via MHC class II "anomaly in the process by which peptide, bound to major histocomptability complex class II, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: EdnrbWS4/EdnrbWS4
Genetic Background: involves: BALB/c * MSM

Allelic Composition: H2-Oatm1Dma/H2-Oatm1Dma
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Oatm1Dma/H2-Oatm1Dma
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdnrbWS4/EdnrbWS4
Genetic Background: involves: BALB/c * MSM

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0012702 increased embryonic neuroepithelium thickness "increased width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
Show

Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / reaction / complex
 ENSMUSG00000037548 H2-DMb2 / histocompatibility 2, class II, locus Mb2 / P28068* / HLA-DMB* / AL645941.2* / major histocompatibility complex, class II, DM beta*  / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex / reaction
 ENSMUSG00000037649 H2-DMa / histocompatibility 2, class II, locus DMa / P28067* / HLA-DMA* / major histocompatibility complex, class II, DM alpha*  / complex
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000041538 H2-Ob / histocompatibility 2, O region beta locus / P13765* / HLA-DOB* / major histocompatibility complex, class II, DO beta*  / complex
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex
 ENSMUSG00000079547 H2-DMb1 / histocompatibility 2, class II, locus Mb1 / P28068* / HLA-DMB* / AL645941.2* / major histocompatibility complex, class II, DM beta*  / complex






 

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