ENSG00000241106


Homo sapiens

Features
Gene ID: ENSG00000241106
  
Biological name :HLA-DOB
  
Synonyms : HLA-DOB / major histocompatibility complex, class II, DO beta / P13765
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.32
Gene start: 32812763
Gene end: 32817048
  
Corresponding Affymetrix probe sets: 1554984_a_at (Human Genome U133 Plus 2.0 Array)   205671_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390020
Ensembl peptide - ENSP00000436618
Ensembl peptide - ENSP00000394860
NCBI entrez gene - 3112     See in Manteia.
OMIM - 600629
RefSeq - NM_002120
RefSeq Peptide - NP_002111
swissprot - H0Y4X4
swissprot - E9PI00
swissprot - P13765
swissprot - Q5QNS2
Ensembl - ENSG00000241106
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU929676.1ENSDARG00000104635Danio rerio
 FO744840.1ENSDARG00000110501Danio rerio
 mhc2bENSDARG00000104730Danio rerio
 mhc2dabENSDARG00000079105Danio rerio
 mhc2dbbENSDARG00000056330Danio rerio
 si:busm1-104n07.3ENSDARG00000074510Danio rerio
 si:busm1-228j01.4ENSDARG00000088872Danio rerio
 si:busm1-228j01.6ENSDARG00000041705Danio rerio
 si:ch73-158p21.3ENSDARG00000101030Danio rerio
 si:zfos-2070c2.3ENSDARG00000076307Danio rerio
 zgc:103700ENSDARG00000116524Danio rerio
 H2-ObENSMUSG00000041538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HLA-DQB1 / major histocompatibility complex, class II, DQ beta 1ENSG0000017934455
P01911 / Q29974 / Q9GIY3 / P04229 / HLA-DRB1 / major histocompatibility complex, class II, DR beta 1ENSG0000019612654
Q30154 / HLA-DRB5 / major histocompatibility complex, class II, DR beta 5ENSG0000019850252
P05538 / HLA-DQB2 / major histocompatibility complex, class II, DQ beta 2ENSG0000023262952
P04440 / HLA-DPB1 / major histocompatibility complex, class II, DP beta 1ENSG0000022386551
P28068 / HLA-DMB / major histocompatibility complex, class II, DM betaENSG0000024257424
AL645941.2ENSG0000024899311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000353  MHC class II, beta chain, N-terminal
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR014745  MHC class II, alpha/beta chain, N-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
 biological_processGO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042613 MHC class II protein complex IEA
 molecular_functionGO:0023026 MHC class II protein complex binding IDA
 molecular_functionGO:0032395 MHC class II receptor activity TAS


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex / reaction
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction
 ENSG00000204257 P28067 / HLA-DMA / major histocompatibility complex, class II, DM alpha  / complex
 ENSG00000204252 P06340 / HLA-DOA / major histocompatibility complex, class II, DO alpha  / complex
 ENSG00000242574 P28068 / HLA-DMB / major histocompatibility complex, class II, DM beta  / complex






 

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