ENSMUSG00000030124


Mus musculus

Features
Gene ID: ENSMUSG00000030124
  
Biological name :Lag3
  
Synonyms : Lag3 / Lymphocyte activation 3 protein / Q61790
  
Possible biological names infered from orthology : lymphocyte activating 3 / P18627
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 124904361
Gene end: 124911705
  
Corresponding Affymetrix probe sets: 10547906 (MoGene1.0st)   1449911_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032217
NCBI entrez gene - 16768     See in Manteia.
MGI - MGI:106588
RefSeq - NM_008479
RefSeq Peptide - NP_032505
swissprot - Q61790
Ensembl - ENSMUSG00000030124
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000044449Gallus gallus
 LAG3ENSG00000089692Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0045085 negative regulation of interleukin-2 biosynthetic process IDA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
 biological_processGO:0050868 negative regulation of T cell activation IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0042289 MHC class II protein binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0001515 abnormal grip strength "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fasntm1Sem/Fasntm1Sem,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Cd4tm1Doi/Cd4tm1Litt,Lag3tm1Doi/Lag3+
Genetic Background: involves: 129 * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm1Doi/Cd4tm1Doi,Lag3tm1Doi/Lag3tm1Doi
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd4tm1Doi/Cd4tm1Litt,Lag3tm1Doi/Lag3+
Genetic Background: involves: 129 * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0008493 alpha-synuclein inclusion body "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex






 

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