ENSMUSG00000033307


Mus musculus

Features
Gene ID: ENSMUSG00000033307
  
Biological name :Mif
  
Synonyms : macrophage migration inhibitory factor (glycosylation-inhibiting factor) / Mif / P34884
  
Possible biological names infered from orthology : macrophage migration inhibitory factor / P14174
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 75859353
Gene end: 75860240
  
Corresponding Affymetrix probe sets: 10370021 (MoGene1.0st)   10561806 (MoGene1.0st)   10590972 (MoGene1.0st)   1416335_at (Mouse Genome 430 2.0 Array)   1433109_at (Mouse Genome 430 2.0 Array)   1454481_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041149
NCBI entrez gene - 17319     See in Manteia.
MGI - MGI:96982
RefSeq - NM_010798
RefSeq Peptide - NP_034928
swissprot - P34884
swissprot - Q545F0
Ensembl - ENSMUSG00000033307
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mifENSDARG00000071336Danio rerio
 MIFENSGALG00000006326Gallus gallus
 MIFENSG00000240972Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001398  Macrophage migration inhibitory factor
 IPR014347  Tautomerase/MIF superfamily
 IPR019829  Macrophage migration inhibitory factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002821 positive regulation of adaptive immune response NAS
 biological_processGO:0002906 negative regulation of mature B cell apoptotic process IDA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007569 cell aging IMP
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010739 positive regulation of protein kinase A signaling IEA
 biological_processGO:0010760 negative regulation of macrophage chemotaxis IEA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0032269 negative regulation of cellular protein metabolic process IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033033 negative regulation of myeloid cell apoptotic process IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0061078 positive regulation of prostaglandin secretion involved in immune response IMP
 biological_processGO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response IMP
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:0090238 positive regulation of arachidonic acid secretion IDA
 biological_processGO:0090344 negative regulation of cell aging IEA
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004167 dopachrome isomerase activity ISO
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0050178 phenylpyruvate tautomerase activity IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm2Sho/Tal1tm2Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Miftm2Gfr/Miftm2Gfr
Genetic Background: C57BL/6-Miftm2Gfr

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pbx3tm1.1Og/Pbx3tm1.1Og
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0004759 decreased mitotic index "decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0010363 increased fibrosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Miftm2Gfr/Miftm2Gfr
Genetic Background: C57BL/6-Miftm2Gfr

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033307 Mif / P34884 / macrophage migration inhibitory factor (glycosylation-inhibiting factor) / P14174* / macrophage migration inhibitory factor*  / complex
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / reaction / complex






 

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