ENSG00000240972


Homo sapiens

Features
Gene ID: ENSG00000240972
  
Biological name :MIF
  
Synonyms : macrophage migration inhibitory factor / MIF / P14174
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q11.23
Gene start: 23894004
Gene end: 23895227
  
Corresponding Affymetrix probe sets: 217871_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000215754
NCBI entrez gene - 4282     See in Manteia.
OMIM - 153620
RefSeq - NM_002415
RefSeq Peptide - NP_002406
swissprot - I4AY87
swissprot - P14174
Ensembl - ENSG00000240972
  
Related genetic diseases (OMIM): 604302 - {Rheumatoid arthritis, systemic juvenile, susceptibility to}, 604302
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mifENSDARG00000071336Danio rerio
 MIFENSGALG00000006326Gallus gallus
 MifENSMUSG00000033307Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001398  Macrophage migration inhibitory factor
 IPR014347  Tautomerase/MIF superfamily
 IPR019829  Macrophage migration inhibitory factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002906 negative regulation of mature B cell apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0010739 positive regulation of protein kinase A signaling IDA
 biological_processGO:0010760 negative regulation of macrophage chemotaxis IDA
 biological_processGO:0019752 carboxylic acid metabolic process IDA
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IDA
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032269 negative regulation of cellular protein metabolic process IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0033033 negative regulation of myeloid cell apoptotic process IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042327 positive regulation of phosphorylation IDA
 biological_processGO:0043030 regulation of macrophage activation NAS
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0061078 positive regulation of prostaglandin secretion involved in immune response IEA
 biological_processGO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response IEA
 biological_processGO:0070207 protein homotrimerization IPI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IDA
 biological_processGO:0090238 positive regulation of arachidonic acid secretion IEA
 biological_processGO:0090344 negative regulation of cell aging IDA
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004167 dopachrome isomerase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0050178 phenylpyruvate tautomerase activity IDA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Neutrophil degranulation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000988 Skin rash 
Show

 HP:0001386 Joint swelling 
Show

 HP:0001701 Pericarditis 
Show

 HP:0001744 Splenomegaly "An abnormal enlargement of the spleen." [HPO:curators]
Show

 HP:0001945 Fever 
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 HP:0002027 Abdominal pain 
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 HP:0002202 Pleural effusion "The presence of an excessive amount of fluid in the pleural cavity." [HPO:curators]
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 HP:0002240 Hepatomegaly "An abnormal enlargment of the liver." [HPO:curators]
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 HP:0002716 Lymphadenopathy 
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 HP:0002829 Arthralgia 
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 HP:0002960 Autoimmune disease 
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 HP:0003565 Elevated erythrocyte sedimentation rate 
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 HP:0005681 Rheumatoid arthritis, juvenile 
Show

 HP:0011227 Elevated C-reactive protein level "An abnormal elevation of the C-reactive protein level in serum." [HPO:probinson]
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 HP:0012122 Anterior uveitis "Inflammation of the uveal tract in which the primary site of inflammation is the anterior chamber." [HPO:probinson]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / complex / reaction
 ENSG00000240972 MIF / P14174 / macrophage migration inhibitory factor  / complex






 

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