ENSMUSG00000027820


Mus musculus

Features
Gene ID: ENSMUSG00000027820
  
Biological name :Mme
  
Synonyms : Mme / Neprilysin / Q61391
  
Possible biological names infered from orthology : membrane metalloendopeptidase / P08473
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E1
Gene start: 63241537
Gene end: 63386030
  
Corresponding Affymetrix probe sets: 10492355 (MoGene1.0st)   1422975_at (Mouse Genome 430 2.0 Array)   1455961_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141469
Ensembl peptide - ENSMUSP00000142259
Ensembl peptide - ENSMUSP00000142205
Ensembl peptide - ENSMUSP00000141544
Ensembl peptide - ENSMUSP00000141483
Ensembl peptide - ENSMUSP00000029400
Ensembl peptide - ENSMUSP00000141452
NCBI entrez gene - 17380     See in Manteia.
MGI - MGI:97004
RefSeq - XM_006501098
RefSeq - NM_001289462
RefSeq - NM_001289463
RefSeq - NM_008604
RefSeq - XM_006501095
RefSeq Peptide - NP_032630
RefSeq Peptide - NP_001276391
RefSeq Peptide - NP_001276392
RefSeq Peptide - NP_001344264
swissprot - Q61391
swissprot - A0A0A6YWA6
swissprot - A0A0A6YY36
swissprot - A0A0A6YW93
swissprot - A0A0A6YWB9
Ensembl - ENSMUSG00000027820
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MMEENSGALG00000010331Gallus gallus
 MMEENSG00000196549Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmel1 / membrane metallo-endopeptidase-like 1 / Q495T6* / membrane metalloendopeptidase like 1*ENSMUSG0000005818353
Ece1 / Q4PZA2 / Endothelin-converting enzyme 1 / P42892*ENSMUSG0000005753037
Phex / P70669 / Metalloendopeptidase homolog PEX / P78562* / phosphate regulating endopeptidase homolog X-linked*ENSMUSG0000005745735
Ece2 / O60344* / EEF1AKMT4-ECE2* / EEF1AKMT4-ECE2 readthrough* / endothelin converting enzyme 2*ENSMUSG0000002284235
Ece2 / O60344* / EEF1AKMT4-ECE2* / EEF1AKMT4-ECE2 readthrough* / endothelin converting enzyme 2*ENSMUSG0000011529335
Ecel1 / Q9JMI0 / Endothelin-converting enzyme-like 1 / O95672*ENSMUSG0000002624732
Kel / Q9EQF2 / Kell blood group glycoprotein homolog / P23276* / Kell blood group, metallo-endopeptidase*ENSMUSG0000002986622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000718  Peptidase M13
 IPR008753  Peptidase M13, N-terminal domain
 IPR018497  Peptidase M13, C-terminal domain
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR029727  Neprilysin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development ISS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006518 peptide metabolic process ISS
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0046449 creatinine metabolic process ISO
 biological_processGO:0050435 amyloid-beta metabolic process IDA
 biological_processGO:0071345 cellular response to cytokine stimulus ISS
 biological_processGO:0071492 cellular response to UV-A ISS
 biological_processGO:0071493 cellular response to UV-B ISO
 biological_processGO:0090399 replicative senescence ISS
 biological_processGO:0097242 amyloid-beta clearance IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005903 brush border ISS
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0044306 neuron projection terminus IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0004175 endopeptidase activity ISO
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008238 exopeptidase activity ISO
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0005151 diffuse hepatic necrosis "disseminated pathologic death of cells within the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031980 Agt / angiotensinogen / P01019*  / reaction






 

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