ENSMUSG00000026247


Mus musculus

Features
Gene ID: ENSMUSG00000026247
  
Biological name :Ecel1
  
Synonyms : Ecel1 / Endothelin-converting enzyme-like 1 / Q9JMI0
  
Possible biological names infered from orthology : O95672
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 87147655
Gene end: 87156521
  
Corresponding Affymetrix probe sets: 10356379 (MoGene1.0st)   1422586_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027463
Ensembl peptide - ENSMUSP00000125096
Ensembl peptide - ENSMUSP00000125557
NCBI entrez gene - 13599     See in Manteia.
MGI - MGI:1343461
RefSeq - XM_017314903
RefSeq - NM_001277925
RefSeq - NM_021306
RefSeq - XM_017314898
RefSeq - XM_017314902
RefSeq Peptide - NP_001264854
RefSeq Peptide - NP_067281
swissprot - Q9JMI0
Ensembl - ENSMUSG00000026247
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ecel1ENSDARG00000060549Danio rerio
 ENSGALG00000030420Gallus gallus
 ENSGALG00000007875Gallus gallus
 ECEL1ENSG00000171551Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ece2 / O60344* / EEF1AKMT4-ECE2* / EEF1AKMT4-ECE2 readthrough* / endothelin converting enzyme 2*ENSMUSG0000011529337
Ece1 / Q4PZA2 / Endothelin-converting enzyme 1 / P42892*ENSMUSG0000005753037
Ece2 / O60344* / EEF1AKMT4-ECE2* / EEF1AKMT4-ECE2 readthrough* / endothelin converting enzyme 2*ENSMUSG0000002284236
Mmel1 / membrane metallo-endopeptidase-like 1 / Q495T6* / membrane metalloendopeptidase like 1*ENSMUSG0000005818333
Mme / Q61391 / Neprilysin / P08473* / membrane metalloendopeptidase*ENSMUSG0000002782031
Phex / P70669 / Metalloendopeptidase homolog PEX / P78562* / phosphate regulating endopeptidase homolog X-linked*ENSMUSG0000005745729
Kel / Q9EQF2 / Kell blood group glycoprotein homolog / P23276* / Kell blood group, metallo-endopeptidase*ENSMUSG0000002986626


Protein motifs (from Interpro)
Interpro ID Name
 IPR000718  Peptidase M13
 IPR008753  Peptidase M13, N-terminal domain
 IPR018497  Peptidase M13, C-terminal domain
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR029736  Endothelin-converting enzyme-like 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
Show

Allelic Composition: Ecel1tm1Hiki/Ecel1tm1Hiki
Genetic Background: B6.129-Ecel1tm1Hiki

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
Show

Allelic Composition: Ecel1tm1Hiki/Ecel1tm1Hiki
Genetic Background: B6.129-Ecel1tm1Hiki

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Ecel1tm1Hiki/Ecel1tm1Hiki
Genetic Background: B6.129-Ecel1tm1Hiki

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Ecel1tm1Hiki/Ecel1tm1Hiki
Genetic Background: B6.129-Ecel1tm1Hiki

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

Allelic Composition: Ecel1tm1Hiki/Ecel1tm1Hiki
Genetic Background: B6.129-Ecel1tm1Hiki

 MP:0002316 anoxia "absence or almost complete absence of oxygen from inspired gases, blood, or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

Allelic Composition: Ecel1tm1Hiki/Ecel1tm1Hiki
Genetic Background: B6.129-Ecel1tm1Hiki

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
Show

Allelic Composition: Ecel1tm1Hiki/Ecel1tm1Hiki
Genetic Background: B6.129-Ecel1tm1Hiki

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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