Manteia

ENSMUSG00000058183

Mus musculus

Features

Gene ID:	ENSMUSG00000058183

Biological name :	Mmel1

Synonyms :	membrane metallo-endopeptidase-like 1 / Mmel1

Possible biological names infered from orthology :	membrane metalloendopeptidase like 1 / Q495T6

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	E2
Gene start:	154869585
Gene end:	154895528

Corresponding Affymetrix probe sets:	10510923 (MoGene1.0st) 1449432_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000078252 Ensembl peptide - ENSMUSP00000131753 Ensembl peptide - ENSMUSP00000121243 Ensembl peptide - ENSMUSP00000101260 Ensembl peptide - ENSMUSP00000101259 Ensembl peptide - ENSMUSP00000079399 NCBI entrez gene - 27390 See in Manteia. MGI - MGI:1351603 RefSeq - NM_013783 RefSeq Peptide - NP_038811 swissprot - B1AS17 swissprot - E9QPA9 swissprot - B1AS15 swissprot - B1AS16 swissprot - E9PVK7 swissprot - B1AS18 Ensembl - ENSMUSG00000058183

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mme / Q61391 / Neprilysin / P08473* / membrane metalloendopeptidase*	ENSMUSG00000027820	52
Ece2 / O60344* / EEF1AKMT4-ECE2* / EEF1AKMT4-ECE2 readthrough* / endothelin converting enzyme 2*	ENSMUSG00000022842	37
Ece1 / Q4PZA2 / Endothelin-converting enzyme 1 / P42892*	ENSMUSG00000057530	37
Ece2 / O60344* / EEF1AKMT4-ECE2* / EEF1AKMT4-ECE2 readthrough* / endothelin converting enzyme 2*	ENSMUSG00000115293	37
Phex / P70669 / Metalloendopeptidase homolog PEX / P78562* / phosphate regulating endopeptidase homolog X-linked*	ENSMUSG00000057457	36
Ecel1 / Q9JMI0 / Endothelin-converting enzyme-like 1 / O95672*	ENSMUSG00000026247	33
Kel / Q9EQF2 / Kell blood group glycoprotein homolog / P23276* / Kell blood group, metallo-endopeptidase*	ENSMUSG00000029866	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR000718	Peptidase M13
IPR008753	Peptidase M13, N-terminal domain
IPR018497	Peptidase M13, C-terminal domain
IPR024079	Metallopeptidase, catalytic domain superfamily
IPR029735	Membrane metallo-endopeptidase-like 1

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004222	metalloendopeptidase activity	IEA
molecular_function	GO:0008237	metallopeptidase activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000242	impaired fertilization	"defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Kcna1^mceph/Kcna1^mceph Genetic Background: BALB/cByJ-Kcna1^mceph/J
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Kcna1^mceph/Kcna1^mceph Genetic Background: BALB/cByJ-Kcna1^mceph/J
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Kcna1^mceph/Kcna1^mceph Genetic Background: BALB/cByJ-Kcna1^mceph/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr