ENSGALG00000010331


Gallus gallus

Features
Gene ID: ENSGALG00000010331
  
Biological name :MME
  
Synonyms : membrane metalloendopeptidase / MME
  
Possible biological names infered from orthology : Neprilysin / P08473 / Q61391
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 23162941
Gene end: 23198332
  
Corresponding Affymetrix probe sets: Gga.10771.1.S1_s_at (Chicken Array)   Gga.8880.1.S1_at (Chicken Array)   Gga.8880.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016796
NCBI entrez gene - 425031     See in Manteia.
RefSeq - NM_001004412
RefSeq Peptide - NP_001004412
swissprot - Q67BJ2
Ensembl - ENSGALG00000010331
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MMEENSG00000196549Homo sapiens
 MmeENSMUSG00000027820Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMEL1 / membrane metalloendopeptidase like 1 / Q495T6* / membrane metallo-endopeptidase-like 1*ENSGALG0000000111559
ECE1 / endothelin converting enzyme 1 / P42892* / Q4PZA2*ENSGALG0000003134336
ECE2* / O60344* / EEF1AKMT4-ECE2* / EEF1AKMT4-ECE2 readthrough* / endothelin converting enzyme 2*ENSGALG0000000627236
PHEX / phosphate-regulating neutral endopeptidase / P78562* / P70669* / Metalloendopeptidase homolog PEX * / phosphate regulating endopeptidase homolog X-linked*ENSGALG0000001637535
KEL / Kell blood group, metallo-endopeptidase / P23276* / Q9EQF2* / Kell blood group glycoprotein homolog *ENSGALG0000001473619
ECEL1* / O95672* / Q9JMI0* / endothelin converting enzyme like 1*ENSGALG0000003042017
ECEL1* / O95672* / Q9JMI0* / endothelin converting enzyme like 1*ENSGALG0000000787510


Protein motifs (from Interpro)
Interpro ID Name
 IPR000718  Peptidase M13
 IPR008753  Peptidase M13, N-terminal domain
 IPR018497  Peptidase M13, C-terminal domain
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR029727  Neprilysin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0046449 creatinine metabolic process IEA
 biological_processGO:0050435 amyloid-beta metabolic process IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071492 cellular response to UV-A IEA
 biological_processGO:0071493 cellular response to UV-B IEA
 biological_processGO:0090399 replicative senescence IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0044306 neuron projection terminus IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008238 exopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011117 AGT / angiotensinogen / P01019*  / reaction






 

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