Manteia - Molecule gene

ENSMUSG00000020681

Mus musculus

Features

Gene ID:	ENSMUSG00000020681

Biological name :	Ace

Synonyms :	Ace / angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 / P09470

Possible biological names infered from orthology :	AC113554.1 / angiotensin I converting enzyme / P12821

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	E1
Gene start:	105967945
Gene end:	105989964

Corresponding Affymetrix probe sets:	10381962 (MoGene1.0st) 1427034_at (Mouse Genome 430 2.0 Array) 1451911_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000001963 Ensembl peptide - ENSMUSP00000001964 Ensembl peptide - ENSMUSP00000119826 NCBI entrez gene - 11421 See in Manteia. MGI - MGI:87874 RefSeq - NM_009598 RefSeq - NM_001281819 RefSeq - NM_207624 RefSeq Peptide - NP_001268748 RefSeq Peptide - NP_033728 RefSeq Peptide - NP_997507 swissprot - Q3TU20 swissprot - P09470 swissprot - F6QCP8 Ensembl - ENSMUSG00000020681

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ace	ENSDARG00000079166	Danio rerio
ACE	ENSGALG00000000498	Gallus gallus
AC113554.1	ENSG00000264813	Homo sapiens
ACE	ENSG00000159640	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ace3 / D0G895 / angiotensin I converting enzyme (peptidyl-dipeptidase A) 3	ENSMUSG00000101605	28
Ace2 / Q8R0I0 / angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 / Q9BYF1* / angiotensin I converting enzyme 2*	ENSMUSG00000015405	21
Q9ESG4 / Tmem27 / Collectrin / CLTRN* / Q9HBJ8* / collectrin, amino acid transport regulator*	ENSMUSG00000015401	3

Protein motifs (from Interpro)

Interpro ID	Name
IPR001548	Peptidase M2, peptidyl-dipeptidase A

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001822	kidney development	ISO
biological_process	GO:0002446	neutrophil mediated immunity	IMP
biological_process	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	ISO
biological_process	GO:0003084	positive regulation of systemic arterial blood pressure	IMP
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0007283	spermatogenesis	IMP
biological_process	GO:0008217	regulation of blood pressure	IDA
biological_process	GO:0010608	posttranscriptional regulation of gene expression	IMP
biological_process	GO:0010629	negative regulation of gene expression	IMP
biological_process	GO:0032091	negative regulation of protein binding	IMP
biological_process	GO:0032092	positive regulation of protein binding	IMP
biological_process	GO:0042447	hormone catabolic process	IDA
biological_process	GO:0043171	peptide catabolic process	ISO
biological_process	GO:0050435	amyloid-beta metabolic process	ISO
biological_process	GO:0050482	arachidonic acid secretion	ISO
biological_process	GO:0060047	heart contraction	IMP
biological_process	GO:0060177	regulation of angiotensin metabolic process	ISO
biological_process	GO:0061098	positive regulation of protein tyrosine kinase activity	IMP
biological_process	GO:0071838	cell proliferation in bone marrow	IMP
biological_process	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	IMP
biological_process	GO:1902033	regulation of hematopoietic stem cell proliferation	IMP
biological_process	GO:1903597	negative regulation of gap junction assembly	IMP
biological_process	GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation	IMP
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005764	lysosome	ISO
cellular_component	GO:0005768	endosome	ISO
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0009897	external side of plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0070062	extracellular exosome	ISO
molecular_function	GO:0003779	actin binding	ISO
molecular_function	GO:0004175	endopeptidase activity	ISO
molecular_function	GO:0004180	carboxypeptidase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008144	drug binding	ISO
molecular_function	GO:0008233	peptidase activity	IMP
molecular_function	GO:0008237	metallopeptidase activity	ISO
molecular_function	GO:0008238	exopeptidase activity	ISO
molecular_function	GO:0008240	tripeptidyl-peptidase activity	ISO
molecular_function	GO:0008241	peptidyl-dipeptidase activity	IDA
molecular_function	GO:0008270	zinc ion binding	ISO
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0031404	chloride ion binding	ISO
molecular_function	GO:0031434	mitogen-activated protein kinase kinase binding	ISO
molecular_function	GO:0031711	bradykinin receptor binding	ISO
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0051019	mitogen-activated protein kinase binding	ISO
molecular_function	GO:0070573	metallodipeptidase activity	ISO

Pathways (from Reactome)

Pathway description

Metabolism of Angiotensinogen to Angiotensins

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ace^tm4Keb/Ace^tm4Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ace^tm4Keb/Ace^tm4Keb,Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0000230	abnormal blood pressure	"altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ace^tm8Keb/Ace^tm8Keb Genetic Background: involves: 129 Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000242	impaired fertilization	"defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0000521	abnormal kidney cortex	"anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: B6.Cg-Apoe^tm1Unc Fas^lpr Allelic Composition: Ace^tm3Unc/Ace^tm3Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000530	abnormal kidney vasculature	"malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ace^tm2Unc/Ace^tm2Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified Allelic Composition: Ace^tm4Keb/Ace^tm4Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ace^tm4Keb/Ace^tm4Keb,Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: B6.Cg-Apoe^tm1Unc Fas^lpr
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: T^4J/t⁶ Genetic Background: involves: BALB/cBy
MP:0001596	hypotension	"sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ace^tm1Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Ace^tm1Unc/Ace^tm1Unc,Ace2^tm1Pngr/Y Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ace^tm1Unc/Ace^tm1Unc,Ace2^tm1Pngr/Ace2^tm1Pngr Genetic Background: involves: 129P2/OlaHsd
MP:0001762	polyuria	"increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm2Keb/Ace^tm2Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001764	abnormal homeostasis	"anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: T^4J/t⁶ Genetic Background: involves: BALB/cBy
MP:0001859	kidney inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001864	vasculitis	"inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ace^tm4Keb/Ace^tm4Keb,Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm2Keb/Ace^tm2Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm2Keb/Ace^tm2Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ret^tm11(RET)Jmi/Ret^tm12(RET)Jmi Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ace2^tm1Pngr/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ace^tm1Unc/Ace^tm1Unc,Ace2^tm1Pngr/Ace2^tm1Pngr Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ace^tm4Keb/Ace^tm4Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ace^tm8Keb/Ace^tm8Keb Genetic Background: involves: 129
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm1Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ace^tm1Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ace^tm3Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Ace^tm3Unc/Ace^tm3Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002842	increased blood pressure	"increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ace^tm3Unc/Ace^tm3Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002871	albuminuria	"presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ace^tm3Unc/Ace^tm3Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002987	abnormal urine osmolarity	"changes in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]	Show Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002988	decreased urine osmolarity	"reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]	Show Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm2Keb/Ace^tm2Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ace^tm4Keb/Ace^tm4Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ace^tm4Keb/Ace^tm4Keb,Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Ace^tm8.1Keb/Ace^tm8.1Keb Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003014	abnormal kidney medulla morphology	"anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003058	increased insulin secretion	"greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Ace^tm1Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003059	decreased insulin secretion	"less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Ace^tm3Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003184	increased ACE activity		Show Allelic Composition: Ace^tm8.1Keb/Ace^tm8.1Keb Genetic Background: involves: 129 * C57BL/6
MP:0003185	decreased ACE activity		Show Allelic Composition: Ace^tm8.1Keb/Ace^tm8.1Keb Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003352	increased circulating renin level	"elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Ace^tm1Keb/Ace^tm5Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003447	reduced tumor growth/size	"less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]	Show Allelic Composition: Olfr151^{tm15(Vmn1r49)Mom}/Olfr151^{tm15(Vmn1r49)Mom} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ace^tm6Keb/Ace⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Ace^tm6Keb/Ace^tm6Keb Genetic Background: involves: 129 * C57BL/6 * CD-1
MP:0003448	altered tumor morphology	"changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Olfr151^{tm15(Vmn1r49)Mom}/Olfr151^{tm15(Vmn1r49)Mom} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003626	kidney medulla hypoplasia		Show Allelic Composition: Ace^tm4Keb/Ace^tm4Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003638	abnormal response/metabolism to endogenous compounds	"altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ace^tm4Keb/Ace^tm4Keb,Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Ace^tm8.1Keb/Ace^tm8.1Keb Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003670	dilated glomerular capsule	"an expansion in volume of the expanded beginning of a nephron that contains the glomerulus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:91499]	Show Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ace^tm4Keb/Ace^tm4Keb,Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0003698	abnormal male reproductive system physiology	"anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003918	decreased kidney weight	"reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm4Keb/Ace^tm4Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ace^tm4Keb/Ace^tm4Keb,Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0004193	abnormal kidney papilla morphology	"any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0004194	abnormal kidney pelvis morphology	"any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified Allelic Composition: Ace^tm4Keb/Ace^tm4Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004937	dilated heart	"stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm7Keb/Ace^tm7Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004970	kidney atrophy	"wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm2Unc/Ace^tm2Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Olfr151^{tm15(Vmn1r49)Mom}/Olfr151^{tm15(Vmn1r49)Mom} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005166	decreased susceptiblity to injury	"less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ace^tm8.1Keb/Ace^tm8.1Keb Genetic Background: involves: 129 * C57BL/6
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ace^tm3Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Ace^tm3Unc/Ace^tm3Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Ace^tm3Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Ace^tm3Unc/Ace^tm3Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005416	abnormal circulating protein level	"anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ace^tm8Keb/Ace^tm8Keb Genetic Background: involves: 129
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified
MP:0005582	increased renin activity	"greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ace^tm8.1Keb/Ace^tm8.1Keb Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Arnt^tm1Bra/Arnt^tm1Bra Genetic Background: B6.129-Arnt^tm1Bra Allelic Composition: Ace^tm1Keb/Ace^tm5Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ace^tm8.1Keb/Ace^tm8.1Keb Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0005619	increased potassium excretion	"greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0006264	decreased systolic blood pressure	"abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm2Keb/Ace^tm2Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ace^tm2Keb/Ace⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ace^tm4Keb/Ace^tm4Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ace^tm4Keb/Ace^tm4Keb,Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Ace^tm7Keb/Ace^tm7Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006319	abnormal epididymal fat pad	"any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm1Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Ace^tm3Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0006373	abnormal circulating angiotensinogen level	"anomaly in the concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006376	decreased circulating angiotensinogen level	"less than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008543	atrial fibrillation	"asynchronous contraction or quivering of individual cardiac muscle fibers in the atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm7Keb/Ace^tm7Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008725	enlarged heart atrium	"increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]	Show Allelic Composition: Ace^tm7Keb/Ace^tm7Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008751	abnormal interleukin level	"deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: Olfr151^{tm15(Vmn1r49)Mom}/Olfr151^{tm15(Vmn1r49)Mom} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm7Keb/Ace^tm7Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0009767	decreased sensitivity to xenobiotic induced morbidity/mortality	"increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm8.1Keb/Ace^tm8.1Keb Genetic Background: involves: 129 * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ace^tm1Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Ace^tm2Unc/Ace^tm2Unc Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu} Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J
MP:0011304	kidney papillary atrophy	"acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0011305	dilated kidney calyx	"an expansion in the lumen volume or area of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:anna]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm2Keb/Ace^tm2Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011307	kidney medulla cysts	"abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]	Show Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified
MP:0011309	abnormal kidney arterial blood vessel morphology	"any structural anomaly of the network of tubes that supply blood to the renal tissues" [MGI:csmith]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm2Keb/Ace^tm2Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011317	abnormal renal artery morphology	"any structural anomaly of the pair of major vessels which arise off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supply the kidneys with blood; small branches of the renal artery also supply the suprarenal gland, the ureter and some surrounding tissues" [MGI:csmith]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011346	renal tubule atrophy	"acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011347	abnormal kidney medullary ray morphology	"any structural anomaly in the center of a renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla" [ISBN:0-683-40008-8, MGI:anna]	Show Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified
MP:0011376	abnormal kidney corticomedullary boundary morphology	"any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0011405	tubulointerstitial nephritis	"diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]	Show Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified
MP:0011422	kidney medulla atrophy	"acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0011423	kidney cortex atrophy	"acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ace^tm1Mcf/Ace^tm1Mcf Genetic Background: Not Specified
MP:0011501	increased glomerular capsule space	"increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]	Show Allelic Composition: Ace^tm2Keb/Ace^tm2Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011541	decreased urine aldosterone level	"a reduced amount of aldosterone in the urine compared to the normal state" [MGI:anna]	Show Allelic Composition: Ace^tm1Keb/Ace^tm1Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0011939	increased food intake	"increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Ace^tm3Unc/Ace⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011941	increased fluid intake	"increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000031980	Agt / angiotensinogen / P01019*	/ reaction

0 s.

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