ENSMUSG00000015401


Mus musculus

Features
Gene ID: ENSMUSG00000015401
  
Biological name :Tmem27
  
Synonyms : Collectrin / Q9ESG4 / Tmem27
  
Possible biological names infered from orthology : CLTRN / collectrin, amino acid transport regulator / Q9HBJ8
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F5
Gene start: 164088830
Gene end: 164118860
  
Corresponding Affymetrix probe sets: 10603059 (MoGene1.0st)   1435064_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123629
Ensembl peptide - ENSMUSP00000015545
Ensembl peptide - ENSMUSP00000107899
NCBI entrez gene - 57394     See in Manteia.
MGI - MGI:1926234
RefSeq - NM_001313719
RefSeq - NM_020626
RefSeq Peptide - NP_001300648
RefSeq Peptide - NP_065651
swissprot - A2AHZ5
swissprot - Q9ESG4
Ensembl - ENSMUSG00000015401
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-194e6.1ENSDARG00000041644Danio rerio
 CLTRNENSGALG00000029168Gallus gallus
 CLTRNENSG00000147003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ace2 / Q8R0I0 / angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 / Q9BYF1* / angiotensin I converting enzyme 2*ENSMUSG0000001540528
Ace / P09470 / angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 / P12821* / AC113554.1* / angiotensin I converting enzyme*ENSMUSG0000002068115
Ace3 / D0G895 / angiotensin I converting enzyme (peptidyl-dipeptidase A) 3ENSMUSG000001016059


Protein motifs (from Interpro)
Interpro ID Name
 IPR001548  Peptidase M2, peptidyl-dipeptidase A
 IPR031588  Collectrin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0035543 positive regulation of SNARE complex assembly ISO
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis ISO
 biological_processGO:0051957 positive regulation of amino acid transport IMP
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031526 brush border membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008241 peptidyl-dipeptidase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Prph2Nmf193/Prph2+
Genetic Background: C57BL/6J-Prph2Nmf193

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prph2Nmf193/Prph2+
Genetic Background: C57BL/6J-Prph2Nmf193

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm2Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm2Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prph2Nmf193/Prph2+
Genetic Background: C57BL/6J-Prph2Nmf193

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Prph2Nmf193/Prph2+
Genetic Background: C57BL/6J-Prph2Nmf193

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003978 decreased circulating carnitine level "lower than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008055 increased urine osmolality "increase in the concentration of ions in the urine compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm2Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009645 crystalluria "excretion of crystalline material in the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010958 abnormal tricarboxylic acid cycle "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011417 abnormal renal transport "any anomaly of the directed movement of substances through the kidney" [MGI:csmith]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm2Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011467 decreased urine urea nitrogen level "abnormally low amounts of nitrogen in the form of urea in the urine" [MGI:csmith]
Show

Allelic Composition: Cltrntm1Thu/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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