ENSMUSG00000015405


Mus musculus

Features
Gene ID: ENSMUSG00000015405
  
Biological name :Ace2
  
Synonyms : Ace2 / angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 / Q8R0I0
  
Possible biological names infered from orthology : angiotensin I converting enzyme 2 / Q9BYF1
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F5
Gene start: 164139332
Gene end: 164188420
  
Corresponding Affymetrix probe sets: 10603066 (MoGene1.0st)   1425102_a_at (Mouse Genome 430 2.0 Array)   1425103_at (Mouse Genome 430 2.0 Array)   1452138_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073626
Ensembl peptide - ENSMUSP00000107890
Ensembl peptide - ENSMUSP00000123313
NCBI entrez gene - 70008     See in Manteia.
MGI - MGI:1917258
RefSeq - NM_001130513
RefSeq - NM_027286
RefSeq Peptide - NP_001123985
RefSeq Peptide - NP_081562
swissprot - Q8R0I0
swissprot - Q3URC9
swissprot - F6X479
Ensembl - ENSMUSG00000015405
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ace2ENSDARG00000016918Danio rerio
 ACE2ENSGALG00000016554Gallus gallus
 ACE2ENSG00000130234Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ace / P09470 / angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 / P12821* / AC113554.1* / angiotensin I converting enzyme*ENSMUSG0000002068134
Ace3 / D0G895 / angiotensin I converting enzyme (peptidyl-dipeptidase A) 3ENSMUSG0000010160532
Q9ESG4 / Tmem27 / Collectrin / CLTRN* / Q9HBJ8* / collectrin, amino acid transport regulator*ENSMUSG000000154018


Protein motifs (from Interpro)
Interpro ID Name
 IPR001548  Peptidase M2, peptidyl-dipeptidase A
 IPR031588  Collectrin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003051 angiotensin-mediated drinking behavior ISO
 biological_processGO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin ISO
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0015827 tryptophan transport IMP
 biological_processGO:0032800 receptor biosynthetic process ISO
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0046813 receptor-mediated virion attachment to host cell ISO
 biological_processGO:0060452 positive regulation of cardiac muscle contraction IMP
 biological_processGO:1903598 positive regulation of gap junction assembly ISO
 biological_processGO:1903779 regulation of cardiac conduction ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001618 virus receptor activity ISO
 molecular_functionGO:0004175 endopeptidase activity ISO
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0004181 metallocarboxypeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008241 peptidyl-dipeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Tal1tm2Sho/Tal1tm2Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tal1tm2Sho/Tal1tm2Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tal1tm2Sho/Tal1tm2Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tal1tm2Sho/Tal1tm2Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm2Sho/Tal1tm2Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003136 yellow coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ace2tm1Lex/Y
Genetic Background: B6;129S5-Ace2tm1Lex/Mmucd

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: GarsNmf249/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: C57BL/6J * CAST/Ei * CBA/J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tal1tm2Sho/Tal1tm2Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Aqp2tm1(AQP2)Suc/Aqp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ace2tm1Pngr/Y,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp2tm1(AQP2)Suc/Aqp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

 MP:0006373 abnormal circulating angiotensinogen level "anomaly in the concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006375 increased circulating angiotensinogen level "greater than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GarsNmf249/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: C57BL/6J * CAST/Ei * CBA/J

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ace2tm1Hira/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GarsNmf249/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: C57BL/6J * CAST/Ei * CBA/J

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
Show

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
Show

Allelic Composition: GarsNmf249/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: C57BL/6J * CAST/Ei * CBA/J

 MP:0020446 increased NAD(P)H oxidase activity "greater ability to catalyze the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide" [GO:0016174]
Show

Allelic Composition: Ace2tm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031980 Agt / angiotensinogen / P01019*  / reaction






 

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