ENSG00000130234


Homo sapiens

Features
Gene ID: ENSG00000130234
  
Biological name :ACE2
  
Synonyms : ACE2 / angiotensin I converting enzyme 2 / Q9BYF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p22.2
Gene start: 15561033
Gene end: 15602148
  
Corresponding Affymetrix probe sets: 219962_at (Human Genome U133 Plus 2.0 Array)   222257_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000252519
Ensembl peptide - ENSP00000389326
NCBI entrez gene - 59272     See in Manteia.
OMIM - 300335
RefSeq - XM_011545552
RefSeq - NM_021804
RefSeq - XM_011545549
RefSeq - XM_011545551
RefSeq Peptide - NP_068576
swissprot - Q9BYF1
Ensembl - ENSG00000130234
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ace2ENSDARG00000016918Danio rerio
 ACE2ENSGALG00000016554Gallus gallus
 Ace2ENSMUSG00000015405Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACE / P12821 / angiotensin I converting enzymeENSG0000015964033
AC113554.1ENSG0000026481332
CLTRN / Q9HBJ8 / collectrin, amino acid transport regulatorENSG000001470037


Protein motifs (from Interpro)
Interpro ID Name
 IPR001548  Peptidase M2, peptidyl-dipeptidase A
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR031588  Collectrin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IC
 biological_processGO:0002003 angiotensin maturation TAS
 biological_processGO:0003051 angiotensin-mediated drinking behavior IMP
 biological_processGO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0015827 tryptophan transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019229 regulation of vasoconstriction IC
 biological_processGO:0032800 receptor biosynthetic process IMP
 biological_processGO:0042127 regulation of cell proliferation TAS
 biological_processGO:0046718 viral entry into host cell TAS
 biological_processGO:0046813 receptor-mediated virion attachment to host cell IDA
 biological_processGO:0050727 regulation of inflammatory response IC
 biological_processGO:0060452 positive regulation of cardiac muscle contraction IEA
 biological_processGO:0097746 regulation of blood vessel diameter IC
 biological_processGO:1903598 positive regulation of gap junction assembly IMP
 biological_processGO:1903779 regulation of cardiac conduction IMP
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IC
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001618 virus receptor activity IDA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0004181 metallocarboxypeptidase activity EXP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008241 peptidyl-dipeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135744 AGT / P01019 / angiotensinogen  / reaction






 

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