ENSMUSG00000040957


Mus musculus

Features
Gene ID: ENSMUSG00000040957
  
Biological name :Cables1
  
Synonyms : Cables1 / CDK5 and ABL1 enzyme substrate 1 / Q9ESJ1
  
Possible biological names infered from orthology : Cdk5 and Abl enzyme substrate 1 / Q8TDN4
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 11839220
Gene end: 11945630
  
Corresponding Affymetrix probe sets: 10453887 (MoGene1.0st)   1422477_at (Mouse Genome 430 2.0 Array)   1441938_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040639
Ensembl peptide - ENSMUSP00000129463
NCBI entrez gene - 63955     See in Manteia.
MGI - MGI:1927065
RefSeq - NM_022021
RefSeq - NM_001146287
RefSeq Peptide - NP_001139759
RefSeq Peptide - NP_071304
swissprot - Q3U148
swissprot - Q9ESJ1
Ensembl - ENSMUSG00000040957
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cables1ENSDARG00000099395Danio rerio
 CABLES1ENSGALG00000014998Gallus gallus
 Q8TDN4ENSG00000134508Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K3M5 / Cables2 / CDK5 and ABL1 enzyme substrate 2 / Q9BTV7* / Cdk5 and Abl enzyme substrate 2*ENSMUSG0000003899045


Protein motifs (from Interpro)
Interpro ID Name
 IPR006671  Cyclin, N-terminal
 IPR012388  CDK5 and ABL1 enzyme substrate 1/2
 IPR013763  Cyclin-like
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Sult1a1tm1Glatt/Sult1a1tm1Glatt,Tg(SULT1A1,SULT1A2)1Glatt/0
Genetic Background: FVB.Cg-Sult1a1tm1Glatt Tg(SULT1A1,SULT1A2)1Glatt

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sult1a1tm1Glatt/Sult1a1tm1Glatt,Tg(SULT1A1,SULT1A2)1Glatt/0
Genetic Background: FVB.Cg-Sult1a1tm1Glatt Tg(SULT1A1,SULT1A2)1Glatt

 MP:0001123 dilated uterus "stretched or enlarged female muscular organ of gestation" [J:50844]
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Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Sult1a1tm1Glatt/Sult1a1tm1Glatt,Tg(SULT1A1,SULT1A2)1Glatt/0
Genetic Background: FVB.Cg-Sult1a1tm1Glatt Tg(SULT1A1,SULT1A2)1Glatt

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sult1a1tm1Glatt/Sult1a1tm1Glatt,Tg(SULT1A1,SULT1A2)1Glatt/0
Genetic Background: FVB.Cg-Sult1a1tm1Glatt Tg(SULT1A1,SULT1A2)1Glatt

Allelic Composition: Cables1Tg(Actb-rtTA,Actb-tTS)138Utr/Cables1+
Genetic Background: CAJcl.Cg-Cables1Tg(Actb-rtTA,Actb-tTS)138Utr

 MP:0004868 endometrial carcinoma "malignant neoplasm arising from the endometrial tissue" [RGD:Rat Genome Database submission]
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Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0004906 enlarged uterus 
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0008222 decreased hippocampal commissure size "reduced size of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cables1Tg(Actb-rtTA,Actb-tTS)138Utr/Cables1+
Genetic Background: CAJcl.Cg-Cables1Tg(Actb-rtTA,Actb-tTS)138Utr

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cables1Tg(Actb-rtTA,Actb-tTS)138Utr/Cables1+
Genetic Background: CAJcl.Cg-Cables1Tg(Actb-rtTA,Actb-tTS)138Utr

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cables1Tg(Actb-rtTA,Actb-tTS)138Utr/Cables1+
Genetic Background: CAJcl.Cg-Cables1Tg(Actb-rtTA,Actb-tTS)138Utr

 MP:0009092 endometrium hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0009094 abnormal endometrial gland morphology "any structural anomaly of the numerous simple or branched tubular glands lined by ciliated columnar epithelium and found in the mucus membrane of the uterus which secrete mucus, lipids, glycogen, and protein; endometrial glands and their secretions (termed histotroph) are critical regulators of peri-implantation embryo survival and implantation as well as establishment of uterine receptivity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / reaction / complex
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / complex / reaction
 ENSMUSG00000031016 Wee1 / P47810 / WEE 1 homolog 1 (S. pombe) / P30291* / WEE1 G2 checkpoint kinase*  / complex / reaction






 

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