ENSMUSG00000027379


Mus musculus

Features
Gene ID: ENSMUSG00000027379
  
Biological name :Bub1
  
Synonyms : Bub1 / mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 2
  
Possible biological names infered from orthology : BUB1 mitotic checkpoint serine/threonine kinase / O43683
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 127801122
Gene end: 127831865
  
Corresponding Affymetrix probe sets: 10487480 (MoGene1.0st)   1424046_at (Mouse Genome 430 2.0 Array)   1438571_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028858
NCBI entrez gene - 12235     See in Manteia.
MGI - MGI:1100510
RefSeq - XM_006498620
RefSeq - NM_001113179
RefSeq - NM_009772
RefSeq Peptide - NP_001106650
RefSeq Peptide - NP_033902
swissprot - A2APR8
Ensembl - ENSMUSG00000027379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bub1ENSDARG00000077029Danio rerio
 BUB1ENSGALG00000008233Gallus gallus
 BUB1ENSG00000169679Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bub1b / Q9Z1S0 / Mitotic checkpoint serine/threonine-protein kinase BUB1 beta / O60566* / BUB1 mitotic checkpoint serine/threonine kinase B*ENSMUSG0000004008416


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013212  Mad3/Bub1 homology region 1
 IPR015661  Mitotic spindle checkpoint protein Bub1/Mad3
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007063 regulation of sister chromatid cohesion IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0051983 regulation of chromosome segregation IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000942 condensed nuclear chromosome outer kinetochore IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bub1tm3.1Jvd/Bub1tm3.1Jvd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Bub1tm2Jvd/Bub1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm2Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn3tm1Pdk/Ptpn3tm1Pdk
Genetic Background: C57BL/6-Ptpn3tm1Pdk

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bub1tm3.1Jvd/Bub1tm3.1Jvd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Bub1tm2Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: B6.129P2-Bub1tm1.1Tvd

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

Allelic Composition: Bub1tm2Jvd/Bub1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm1.1Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm2Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm1.1Tvd/Bub1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bub1tm3.1Jvd/Bub1tm3.1Jvd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

Allelic Composition: Bub1tm2Jvd/Bub1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm1.1Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm2Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bub1tm3.1Jvd/Bub1tm3.1Jvd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

Allelic Composition: Bub1tm2Jvd/Bub1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm1.1Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm2Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0004759 decreased mitotic index "decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bub1tm3.1Jvd/Bub1tm3.1Jvd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bub1tm1.1Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm1.1Tvd/Bub1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Bub1tm3.1Jvd/Bub1tm3.1Jvd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009277 brain tumor "presence of abnormal rapidly proliferating cells in the brain, usually in the form of a distinct mass" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0009762 abnormal mitotic spindle assembly checkpoint "an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:19372138]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bub1tm1.1Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm2Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: B6.129P2-Bub1tm1.1Tvd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Bub1tm2Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: B6.129P2-Bub1tm1.1Tvd

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Bub1tm1.1Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

Allelic Composition: Bub1tm2Jvd/Bub1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm1.1Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bub1tm2Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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