ENSG00000116819


Homo sapiens

Features
Gene ID: ENSG00000116819
  
Biological name :TFAP2E
  
Synonyms : Q6VUC0 / TFAP2E / transcription factor AP-2 epsilon
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.3
Gene start: 35573370
Gene end: 35595328
  
Corresponding Affymetrix probe sets: 1555348_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362332
NCBI entrez gene - 339488     See in Manteia.
OMIM - 614428
RefSeq - NM_178548
RefSeq - XM_017001139
RefSeq Peptide - NP_848643
swissprot - Q6VUC0
Ensembl - ENSG00000116819
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfap2eENSDARG00000008861Danio rerio
 TFAP2EENSGALG00000039497Gallus gallus
 Q6VUP9ENSMUSG00000042477Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q92481 / TFAP2B / transcription factor AP-2 betaENSG0000000819662
P05549 / TFAP2A / transcription factor AP-2 alphaENSG0000013720360
Q92754 / TFAP2C / transcription factor AP-2 gammaENSG0000008751052
Q7Z6R9 / TFAP2D / transcription factor AP-2 deltaENSG0000000819748


Protein motifs (from Interpro)
Interpro ID Name
 IPR004979  Transcription factor AP-2
 IPR013854  Transcription factor AP-2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048856 anatomical structure development IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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