ENSG00000180573


Homo sapiens

Features
Gene ID: ENSG00000180573
  
Biological name :HIST1H2AC
  
Synonyms : HIST1H2AC / histone cluster 1 H2A family member c / Q93077
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.2
Gene start: 26124145
Gene end: 26139116
  
Corresponding Affymetrix probe sets: 215071_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000367022
Ensembl peptide - ENSP00000473534
Ensembl peptide - ENSP00000321389
NCBI entrez gene - 8334     See in Manteia.
OMIM - 602794
RefSeq - NM_003512
RefSeq Peptide - NP_003503
swissprot - A0A024R017
swissprot - Q93077
Ensembl - ENSG00000180573
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7L7L0 / HIST3H2A / histone cluster 3 H2AENSG0000018121899
P0C0S8 / HIST1H2AI / histone cluster 1 H2A family member iENSG0000019674798
P0C0S8 / HIST1H2AK / histone cluster 1 H2A family member kENSG0000027522198
Q6FI13 / HIST2H2AA4 / histone cluster 2 H2A family member a4ENSG0000027219698
P0C0S8 / HIST1H2AG / histone cluster 1 H2A family member gENSG0000019678798
P0C0S8 / HIST1H2AM / histone cluster 1 H2A family member mENSG0000027867798
P20671 / HIST1H2AD / histone cluster 1 H2A family member dENSG0000019686698
Q6FI13 / HIST2H2AA3 / histone cluster 2 H2A family member a3ENSG0000020381298
P0C0S8 / HIST1H2AL / histone cluster 1 H2A family member lENSG0000027690398
AL031777.3ENSG0000028298897
Q16777 / HIST2H2AC / histone cluster 2 H2A family member cENSG0000018426097
Q96KK5 / HIST1H2AH / histone cluster 1 H2A family member hENSG0000027499797
Q99878 / HIST1H2AJ / histone cluster 1 H2A family member jENSG0000027636896
Q8IUE6 / HIST2H2AB / histone cluster 2 H2A family member bENSG0000018427095
Q96QV6 / HIST1H2AA / histone cluster 1 H2A family member aENSG0000016450894
H2AFJ / Q9BTM1 / H2A histone family member JENSG0000024670593
H2AFX / P16104 / H2A histone family member XENSG0000018848692
H2AFY2 / Q9P0M6 / H2A histone family member Y2ENSG0000009928465
H2AFY / O75367 / H2A histone family member YENSG0000011364865
H2AFB2 / P0C5Z0 / H2A histone family member B2ENSG0000027785839


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex / reaction
 ENSG00000136997 MYC / P01106 / MYC proto-oncogene, bHLH transcription factor  / reaction / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000180573 Q93077 / HIST1H2AC / histone cluster 1 H2A family member c  / complex / reaction
 ENSG00000004487 KDM1A / O60341 / lysine demethylase 1A  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction / complex






 

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