ENSG00000246705


Homo sapiens

Features
Gene ID: ENSG00000246705
  
Biological name :H2AFJ
  
Synonyms : H2AFJ / H2A histone family member J / Q9BTM1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p12.3
Gene start: 14774383
Gene end: 14778002
  
Corresponding Affymetrix probe sets: 220936_s_at (Human Genome U133 Plus 2.0 Array)   224301_x_at (Human Genome U133 Plus 2.0 Array)   225245_x_at (Human Genome U133 Plus 2.0 Array)   228213_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438553
Ensembl peptide - ENSP00000440902
Ensembl peptide - ENSP00000373730
NCBI entrez gene - 55766     See in Manteia.
RefSeq - NM_177925
RefSeq Peptide - NP_808760
swissprot - A0A024RAS2
swissprot - H0YFX9
swissprot - Q9BTM1
Ensembl - ENSG00000246705
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P02263ENSGALG00000031571Gallus gallus
 P02263ENSGALG00000027315Gallus gallus
 P02263ENSGALG00000032645Gallus gallus
 P02263ENSGALG00000027113Gallus gallus
 P02263ENSGALG00000028372Gallus gallus
 P02263ENSGALG00000035715Gallus gallus
 P02263ENSGALG00000029941Gallus gallus
 H2afjENSMUSG00000060032Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96KK5 / HIST1H2AH / histone cluster 1 H2A family member hENSG0000027499794
P0C0S8 / HIST1H2AG / histone cluster 1 H2A family member gENSG0000019678794
Q99878 / HIST1H2AJ / histone cluster 1 H2A family member jENSG0000027636894
P0C0S8 / HIST1H2AI / histone cluster 1 H2A family member iENSG0000019674794
P0C0S8 / HIST1H2AL / histone cluster 1 H2A family member lENSG0000027690394
Q6FI13 / HIST2H2AA3 / histone cluster 2 H2A family member a3ENSG0000020381294
P0C0S8 / HIST1H2AK / histone cluster 1 H2A family member kENSG0000027522194
Q16777 / HIST2H2AC / histone cluster 2 H2A family member cENSG0000018426094
Q93077 / HIST1H2AC / histone cluster 1 H2A family member cENSG0000018057394
Q8IUE6 / HIST2H2AB / histone cluster 2 H2A family member bENSG0000018427094
Q6FI13 / HIST2H2AA4 / histone cluster 2 H2A family member a4ENSG0000027219694
P0C0S8 / HIST1H2AM / histone cluster 1 H2A family member mENSG0000027867794
AL031777.3ENSG0000028298893
P20671 / HIST1H2AD / histone cluster 1 H2A family member dENSG0000019686693
Q7L7L0 / HIST3H2A / histone cluster 3 H2AENSG0000018121893
H2AFX / P16104 / H2A histone family member XENSG0000018848691
Q96QV6 / HIST1H2AA / histone cluster 1 H2A family member aENSG0000016450890
H2AFY2 / Q9P0M6 / H2A histone family member Y2ENSG0000009928464
H2AFY / O75367 / H2A histone family member YENSG0000011364863
H2AFB2 / P0C5Z0 / H2A histone family member B2ENSG0000027785840


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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