ENSG00000113648


Homo sapiens

Features
Gene ID: ENSG00000113648
  
Biological name :H2AFY
  
Synonyms : H2AFY / H2A histone family member Y / O75367
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.1
Gene start: 135333900
Gene end: 135399914
  
Corresponding Affymetrix probe sets: 207168_s_at (Human Genome U133 Plus 2.0 Array)   214500_at (Human Genome U133 Plus 2.0 Array)   214501_s_at (Human Genome U133 Plus 2.0 Array)   226840_at (Human Genome U133 Plus 2.0 Array)   229593_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423563
Ensembl peptide - ENSP00000415121
Ensembl peptide - ENSP00000423718
Ensembl peptide - ENSP00000424971
Ensembl peptide - ENSP00000302572
Ensembl peptide - ENSP00000310169
NCBI entrez gene - 9555     See in Manteia.
OMIM - 610054
RefSeq - XM_017010069
RefSeq - XM_005272132
RefSeq - XM_011543729
RefSeq - XM_011543730
RefSeq - XM_011543731
RefSeq - XM_011543732
RefSeq - XM_011543733
RefSeq - XM_017010067
RefSeq - NM_001040158
RefSeq - NM_004893
RefSeq - NM_138609
RefSeq - NM_138610
RefSeq Peptide - NP_613258
RefSeq Peptide - NP_001035248
RefSeq Peptide - NP_004884
RefSeq Peptide - NP_613075
swissprot - O75367
swissprot - D6RCF2
swissprot - B4DJC3
Ensembl - ENSG00000113648
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 h2afyENSDARG00000099329Danio rerio
 H2AFYENSGALG00000040141Gallus gallus
 H2afyENSMUSG00000015937Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2AFY2 / Q9P0M6 / H2A histone family member Y2ENSG0000009928468
H2AFX / P16104 / H2A histone family member XENSG0000018848624
AL031777.3ENSG0000028298823
Q6FI13 / HIST2H2AA3 / histone cluster 2 H2A family member a3ENSG0000020381223
Q6FI13 / HIST2H2AA4 / histone cluster 2 H2A family member a4ENSG0000027219623
Q7L7L0 / HIST3H2A / histone cluster 3 H2AENSG0000018121823
Q93077 / HIST1H2AC / histone cluster 1 H2A family member cENSG0000018057323
Q8IUE6 / HIST2H2AB / histone cluster 2 H2A family member bENSG0000018427022
P20671 / HIST1H2AD / histone cluster 1 H2A family member dENSG0000019686622
P0C0S8 / HIST1H2AL / histone cluster 1 H2A family member lENSG0000027690322
H2AFJ / Q9BTM1 / H2A histone family member JENSG0000024670522
Q96QV6 / HIST1H2AA / histone cluster 1 H2A family member aENSG0000016450822
P0C0S8 / HIST1H2AI / histone cluster 1 H2A family member iENSG0000019674722
P0C0S8 / HIST1H2AK / histone cluster 1 H2A family member kENSG0000027522122
P0C0S8 / HIST1H2AM / histone cluster 1 H2A family member mENSG0000027867722
Q96KK5 / HIST1H2AH / histone cluster 1 H2A family member hENSG0000027499722
Q16777 / HIST2H2AC / histone cluster 2 H2A family member cENSG0000018426022
Q99878 / HIST1H2AJ / histone cluster 1 H2A family member jENSG0000027636822
P0C0S8 / HIST1H2AG / histone cluster 1 H2A family member gENSG0000019678722
H2AFB2 / P0C5Z0 / H2A histone family member B2ENSG0000027785811


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR002589  Macro domain
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR021171  Core histone macro-H2A
 IPR032454  Histone H2A, C-terminal domain
 IPR035796  Core histone macro-H2A, macro domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006334 nucleosome assembly NAS
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0007549 dosage compensation IDA
 biological_processGO:0019216 regulation of lipid metabolic process IMP
 biological_processGO:0033128 negative regulation of histone phosphorylation IMP
 biological_processGO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion IDA
 biological_processGO:0040029 regulation of gene expression, epigenetic IMP
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IMP
 biological_processGO:0045814 negative regulation of gene expression, epigenetic IMP
 biological_processGO:0045815 positive regulation of gene expression, epigenetic IMP
 biological_processGO:0051572 negative regulation of histone H3-K4 methylation IMP
 biological_processGO:0061086 negative regulation of histone H3-K27 methylation IMP
 biological_processGO:0071169 establishment of protein localization to chromatin IMP
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IMP
 biological_processGO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
 biological_processGO:1902750 negative regulation of cell cycle G2/M phase transition IMP
 biological_processGO:1902882 regulation of response to oxidative stress IMP
 biological_processGO:1904815 negative regulation of protein localization to chromosome, telomeric region IDA
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000786 nucleosome NAS
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0001739 sex chromatin TAS
 cellular_componentGO:0001740 Barr body IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005721 pericentric heterochromatin IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000182 rDNA binding IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0010385 double-stranded methylated DNA binding IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity IMP
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0031492 nucleosomal DNA binding ISS
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr