ENSG00000276368


Homo sapiens

Features
Gene ID: ENSG00000276368
  
Biological name :HIST1H2AJ
  
Synonyms : HIST1H2AJ / histone cluster 1 H2A family member j / Q99878
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p22.1
Gene start: 27814354
Gene end: 27814740
  
Corresponding Affymetrix probe sets: 208583_x_at (Human Genome U133 Plus 2.0 Array)   214542_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000328484
NCBI entrez gene - 8331     See in Manteia.
OMIM - 602791
RefSeq - NM_021066
RefSeq Peptide - NP_066544
swissprot - Q99878
Ensembl - ENSG00000276368
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P0C0S8 / HIST1H2AK / histone cluster 1 H2A family member kENSG0000027522199
P0C0S8 / HIST1H2AG / histone cluster 1 H2A family member gENSG0000019678799
P0C0S8 / HIST1H2AI / histone cluster 1 H2A family member iENSG0000019674799
P0C0S8 / HIST1H2AL / histone cluster 1 H2A family member lENSG0000027690399
P0C0S8 / HIST1H2AM / histone cluster 1 H2A family member mENSG0000027867799
Q96KK5 / HIST1H2AH / histone cluster 1 H2A family member hENSG0000027499799
Q6FI13 / HIST2H2AA3 / histone cluster 2 H2A family member a3ENSG0000020381298
AL031777.3ENSG0000028298898
Q6FI13 / HIST2H2AA4 / histone cluster 2 H2A family member a4ENSG0000027219698
Q93077 / HIST1H2AC / histone cluster 1 H2A family member cENSG0000018057398
P20671 / HIST1H2AD / histone cluster 1 H2A family member dENSG0000019686698
Q16777 / HIST2H2AC / histone cluster 2 H2A family member cENSG0000018426097
Q7L7L0 / HIST3H2A / histone cluster 3 H2AENSG0000018121897
H2AFJ / Q9BTM1 / H2A histone family member JENSG0000024670595
Q8IUE6 / HIST2H2AB / histone cluster 2 H2A family member bENSG0000018427095
Q96QV6 / HIST1H2AA / histone cluster 1 H2A family member aENSG0000016450893
H2AFX / P16104 / H2A histone family member XENSG0000018848692
H2AFY2 / Q9P0M6 / H2A histone family member Y2ENSG0000009928464
H2AFY / O75367 / H2A histone family member YENSG0000011364864
H2AFB3 / P0C5Z0 / H2A histone family member B3ENSG0000027774539


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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