ENSMUSG00000015937


Mus musculus

Features
Gene ID: ENSMUSG00000015937
  
Biological name :H2afy
  
Synonyms : Core histone macro-H2A.1 / H2afy / Q9QZQ8
  
Possible biological names infered from orthology : H2A histone family member Y / O75367
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 56073619
Gene end: 56136361
  
Corresponding Affymetrix probe sets: 10409557 (MoGene1.0st)   1424572_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016081
Ensembl peptide - ENSMUSP00000038221
NCBI entrez gene - 26914     See in Manteia.
MGI - MGI:1349392
RefSeq - NM_001159515
RefSeq - NM_001159513
RefSeq - NM_001159514
RefSeq - NM_012015
RefSeq Peptide - NP_001152985
RefSeq Peptide - NP_001152986
RefSeq Peptide - NP_001152987
RefSeq Peptide - NP_036145
swissprot - Q9QZQ8
Ensembl - ENSMUSG00000015937
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 h2afyENSDARG00000099329Danio rerio
 H2AFYENSGALG00000040141Gallus gallus
 H2AFYENSG00000113648Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2afy2 / Q8CCK0 / Core histone macro-H2A.2 / Q9P0M6* / H2A histone family member Y2*ENSMUSG0000002008667
H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*ENSMUSG0000004993223
Q6GSS7 / Hist2h2aa2 / Histone H2A type 2-A ENSMUSG0000006395423
Q6GSS7 / Hist2h2aa1 / Histone H2A type 2-A / Q16777* / Q6FI13* / HIST2H2AC* / HIST2H2AA4* / histone cluster 2 H2A family member c* / histone cluster 2 H2A family member a4*ENSMUSG0000006422023
Q64522 / Hist2h2ab / Histone H2A type 2-B / Q8IUE6* / histone cluster 2 H2A family member b*ENSMUSG0000006368923
Q8BFU2 / Hist3h2a / Histone H2A type 3 / Q7L7L0* / histone cluster 3 H2A*ENSMUSG0000007885122
H2afj / Q8R1M2 / Histone H2A.J / Q9BTM1* / H2A histone family member J*ENSMUSG0000006003222
Q8CGP5 / Hist1h2af / Histone H2A type 1-F ENSMUSG0000006199122
Q64523 / Hist2h2ac / Histone H2A type 2-C ENSMUSG0000006885522
Q8CGP7 / Hist1h2ak / Histone H2A type 1-K ENSMUSG0000006302122
Hist1h2aa / histone cluster 1, H2aa / Q96QV6* / histone cluster 1 H2A family member a*ENSMUSG0000006008121
H2afb1 / H2AFB3* / P0C5Z0* / H2AFB2* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG000000674419
H2afb3 / H2AFB2* / P0C5Z0* / H2AFB1* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG000000836169
H2afb2 / H2AFB3* / P0C5Z0* / H2AFB1* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG000000824828


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR002589  Macro domain
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR021171  Core histone macro-H2A
 IPR032454  Histone H2A, C-terminal domain
 IPR035796  Core histone macro-H2A, macro domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0007549 dosage compensation ISO
 biological_processGO:0019216 regulation of lipid metabolic process ISO
 biological_processGO:0031060 regulation of histone methylation IBA
 biological_processGO:0033128 negative regulation of histone phosphorylation ISO
 biological_processGO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion ISO
 biological_processGO:0040029 regulation of gene expression, epigenetic ISO
 biological_processGO:0045618 positive regulation of keratinocyte differentiation ISO
 biological_processGO:0045814 negative regulation of gene expression, epigenetic ISO
 biological_processGO:0045815 positive regulation of gene expression, epigenetic ISO
 biological_processGO:0051572 negative regulation of histone H3-K4 methylation ISO
 biological_processGO:0061086 negative regulation of histone H3-K27 methylation ISO
 biological_processGO:0071169 establishment of protein localization to chromatin ISO
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity ISO
 biological_processGO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
 biological_processGO:1902750 negative regulation of cell cycle G2/M phase transition ISO
 biological_processGO:1902882 regulation of response to oxidative stress IMP
 biological_processGO:1902883 negative regulation of response to oxidative stress ISO
 biological_processGO:1902884 positive regulation of response to oxidative stress ISO
 biological_processGO:1904815 negative regulation of protein localization to chromosome, telomeric region ISO
 cellular_componentGO:0000228 nuclear chromosome ISO
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0001740 Barr body ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005721 pericentric heterochromatin ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005813 centrosome TAS
 cellular_componentGO:0035098 ESC/E(Z) complex ISO
 molecular_functionGO:0000182 rDNA binding ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0010385 double-stranded methylated DNA binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity ISO
 molecular_functionGO:0031490 chromatin DNA binding ISO
 molecular_functionGO:0031492 nucleosomal DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpin1fld/Lpin1fld
Genetic Background: BALB/cByJ-Lpin1fld

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003671 abnormal eyelid opening 
Show

Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013745 abnormal eyelid margin morphology "any structural anomaly of the confluence of the mucosal surface of the conjunctiva, the edge of the orbicularis, and the cutaneous epithelium" [http://one.aao.org/bcscsnippetdetail.aspx?id=2b7328d7-5eb2-4df3-812a-031ff1c1f904, http://www.medilexicon.com/medicaldictionary.php?s=palpebral+margins, MGI:Anna]
Show

Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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