ENSMUSG00000060032


Mus musculus

Features
Gene ID: ENSMUSG00000060032
  
Biological name :H2afj
  
Synonyms : H2afj / Histone H2A.J / Q8R1M2
  
Possible biological names infered from orthology : H2A histone family member J / Q9BTM1
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G1
Gene start: 136808244
Gene end: 136810074
  
Corresponding Affymetrix probe sets: 10542397 (MoGene1.0st)   1424771_at (Mouse Genome 430 2.0 Array)   1424772_at (Mouse Genome 430 2.0 Array)   1440252_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144974
Ensembl peptide - ENSMUSP00000074142
NCBI entrez gene - 232440     See in Manteia.
MGI - MGI:3606192
RefSeq - NM_177688
RefSeq Peptide - NP_808356
swissprot - A0A0N4SV66
swissprot - Q8R1M2
Ensembl - ENSMUSG00000060032
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P02263ENSGALG00000027315Gallus gallus
 P02263ENSGALG00000032645Gallus gallus
 P02263ENSGALG00000027113Gallus gallus
 P02263ENSGALG00000028372Gallus gallus
 P02263ENSGALG00000035715Gallus gallus
 P02263ENSGALG00000029941Gallus gallus
 P02263ENSGALG00000031571Gallus gallus
 H2AFJENSG00000246705Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BFU2 / Hist3h2a / Histone H2A type 3 / Q7L7L0* / histone cluster 3 H2A*ENSMUSG0000007885194
Q8CGP5 / Hist1h2af / Histone H2A type 1-F ENSMUSG0000006199193
Q6GSS7 / Hist2h2aa1 / Histone H2A type 2-A / Q16777* / Q6FI13* / HIST2H2AC* / HIST2H2AA4* / histone cluster 2 H2A family member c* / histone cluster 2 H2A family member a4*ENSMUSG0000006422093
Q6GSS7 / Hist2h2aa2 / Histone H2A type 2-A ENSMUSG0000006395493
Q64522 / Hist2h2ab / Histone H2A type 2-B / Q8IUE6* / histone cluster 2 H2A family member b*ENSMUSG0000006368993
Q64523 / Hist2h2ac / Histone H2A type 2-C ENSMUSG0000006885593
Q8CGP7 / Hist1h2ak / Histone H2A type 1-K ENSMUSG0000006302192
H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*ENSMUSG0000004993291
Hist1h2aa / histone cluster 1, H2aa / Q96QV6* / histone cluster 1 H2A family member a*ENSMUSG0000006008188
H2afy2 / Q8CCK0 / Core histone macro-H2A.2 / Q9P0M6* / H2A histone family member Y2*ENSMUSG0000002008664
H2afy / Q9QZQ8 / Core histone macro-H2A.1 / O75367* / H2A histone family member Y*ENSMUSG0000001593763
H2afb3 / H2AFB2* / P0C5Z0* / H2AFB1* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG0000008361633
H2afb1 / H2AFB3* / P0C5Z0* / H2AFB2* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG0000006744133
H2afb2 / H2AFB3* / P0C5Z0* / H2AFB1* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG0000008248230


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006342 chromatin silencing IBA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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