ENSMUSG00000064220


Mus musculus

Features
Gene ID: ENSMUSG00000064220
  
Biological name :Hist2h2aa1
  
Synonyms : Hist2h2aa1 / Histone H2A type 2-A / Q6GSS7
  
Possible biological names infered from orthology : HIST2H2AA4 / HIST2H2AC / histone cluster 2 H2A family member a4 / histone cluster 2 H2A family member c / Q16777 / Q6FI13
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 96245497
Gene end: 96246082
  
Corresponding Affymetrix probe sets: 10403955 (MoGene1.0st)   10404026 (MoGene1.0st)   10404045 (MoGene1.0st)   10408072 (MoGene1.0st)   10408085 (MoGene1.0st)   10408094 (MoGene1.0st)   10408111 (MoGene1.0st)   10409220 (MoGene1.0st)   10494386 (MoGene1.0st)   10494390 (MoGene1.0st)   10494395 (MoGene1.0st)   10500324 (MoGene1.0st)   10500329 (MoGene1.0st)   1418366_at (Mouse Genome 430 2.0 Array)   1418367_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077814
NCBI entrez gene - 15267     See in Manteia.
MGI - MGI:96097
RefSeq - NM_013549
RefSeq Peptide - NP_038577
swissprot - B2RWH3
swissprot - Q6GSS7
Ensembl - ENSMUSG00000064220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 H2AFJENSGALG00000038343Gallus gallus
 Q16777ENSG00000184260Homo sapiens
 Q6FI13ENSG00000272196Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6GSS7 / Hist2h2aa2 / Histone H2A type 2-A ENSMUSG00000063954100
Q64523 / Hist2h2ac / Histone H2A type 2-C ENSMUSG0000006885598
Q8BFU2 / Hist3h2a / Histone H2A type 3 / Q7L7L0* / histone cluster 3 H2A*ENSMUSG0000007885198
Q8CGP7 / Hist1h2ak / Histone H2A type 1-K ENSMUSG0000006302196
Q8CGP5 / Hist1h2af / Histone H2A type 1-F ENSMUSG0000006199196
Q64522 / Hist2h2ab / Histone H2A type 2-B / Q8IUE6* / histone cluster 2 H2A family member b*ENSMUSG0000006368995
H2afj / Q8R1M2 / Histone H2A.J / Q9BTM1* / H2A histone family member J*ENSMUSG0000006003292
H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*ENSMUSG0000004993290
Hist1h2aa / histone cluster 1, H2aa / Q96QV6* / histone cluster 1 H2A family member a*ENSMUSG0000006008188
H2afy / Q9QZQ8 / Core histone macro-H2A.1 / O75367* / H2A histone family member Y*ENSMUSG0000001593765
H2afy2 / Q8CCK0 / Core histone macro-H2A.2 / Q9P0M6* / H2A histone family member Y2*ENSMUSG0000002008665
H2afb1 / H2AFB3* / P0C5Z0* / H2AFB2* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG0000006744132
H2afb3 / H2AFB2* / P0C5Z0* / H2AFB1* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG0000008361632
H2afb2 / H2AFB3* / P0C5Z0* / H2AFB1* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG0000008248229


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006334 nucleosome assembly NAS
 biological_processGO:0006342 chromatin silencing IBA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr