ENSG00000274183


Homo sapiens

Features
Gene ID: ENSG00000274183
  
Biological name :H2AFB1
  
Synonyms : H2AFB1 / H2A histone family member B1 / P0C5Y9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q28
Gene start: 154884972
Gene end: 154885558
  
Corresponding Affymetrix probe sets: 214412_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484261
NCBI entrez gene - 474382     See in Manteia.
RefSeq - NM_001017990
RefSeq Peptide - NP_001017990
swissprot - P0C5Y9
Ensembl - ENSG00000274183
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000015609Gallus gallus
 H2afb1ENSMUSG00000067441Mus musculus
 H2afb2ENSMUSG00000082482Mus musculus
 H2afb3ENSMUSG00000083616Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2AFB3 / P0C5Z0 / H2A histone family member B3ENSG0000027774599
H2AFB2 / P0C5Z0 / H2A histone family member B2ENSG0000027785899
Q8IUE6 / HIST2H2AB / histone cluster 2 H2A family member bENSG0000018427044
H2AFX / P16104 / H2A histone family member XENSG0000018848644
Q6FI13 / HIST2H2AA4 / histone cluster 2 H2A family member a4ENSG0000027219643
P0C0S8 / HIST1H2AM / histone cluster 1 H2A family member mENSG0000027867743
Q96KK5 / HIST1H2AH / histone cluster 1 H2A family member hENSG0000027499743
P0C0S8 / HIST1H2AK / histone cluster 1 H2A family member kENSG0000027522143
P0C0S8 / HIST1H2AI / histone cluster 1 H2A family member iENSG0000019674743
P0C0S8 / HIST1H2AL / histone cluster 1 H2A family member lENSG0000027690343
Q6FI13 / HIST2H2AA3 / histone cluster 2 H2A family member a3ENSG0000020381243
H2AFJ / Q9BTM1 / H2A histone family member JENSG0000024670543
Q7L7L0 / HIST3H2A / histone cluster 3 H2AENSG0000018121843
Q93077 / HIST1H2AC / histone cluster 1 H2A family member cENSG0000018057343
Q16777 / HIST2H2AC / histone cluster 2 H2A family member cENSG0000018426043
P0C0S8 / HIST1H2AG / histone cluster 1 H2A family member gENSG0000019678743
Q99878 / HIST1H2AJ / histone cluster 1 H2A family member jENSG0000027636843
Q96QV6 / HIST1H2AA / histone cluster 1 H2A family member aENSG0000016450842
P20671 / HIST1H2AD / histone cluster 1 H2A family member dENSG0000019686642
AL031777.3ENSG0000028298842


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006334 nucleosome assembly IDA
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0006397 mRNA processing IMP
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000788 nuclear nucleosome IDA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0035327 transcriptionally active chromatin IDA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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