ENSG00000132510


Homo sapiens

Features
Gene ID: ENSG00000132510
  
Biological name :KDM6B
  
Synonyms : KDM6B / lysine demethylase 6B / O15054
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 7839904
Gene end: 7854796
  
Corresponding Affymetrix probe sets: 1556066_at (Human Genome U133 Plus 2.0 Array)   1556067_a_at (Human Genome U133 Plus 2.0 Array)   213146_at (Human Genome U133 Plus 2.0 Array)   41386_i_at (Human Genome U133 Plus 2.0 Array)   41387_r_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000254846
Ensembl peptide - ENSP00000412513
Ensembl peptide - ENSP00000458445
NCBI entrez gene - 23135     See in Manteia.
OMIM - 611577
RefSeq - XM_017024381
RefSeq - NM_001080424
RefSeq - XM_005256552
RefSeq - XM_006721483
RefSeq - XM_011523750
RefSeq - XM_011523752
RefSeq - XM_005256549
RefSeq - XM_005256550
RefSeq - XM_005256551
RefSeq Peptide - NP_001073893
RefSeq Peptide - NP_001335645
swissprot - O15054
swissprot - I3L0Z0
Ensembl - ENSG00000132510
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm6baENSDARG00000088087Danio rerio
 Kdm6bENSMUSG00000018476Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM6A / O15550 / lysine demethylase 6AENSG0000014705027
UTY / O14607 / ubiquitously transcribed tetratricopeptide repeat containing, Y-linkedENSG0000018387826


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR029518  Lysine-specific demethylase 6B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling ISS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016577 histone demethylation IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045446 endothelial cell differentiation ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048333 mesodermal cell differentiation ISS
 biological_processGO:0055007 cardiac muscle cell differentiation ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060992 response to fungicide IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071557 histone H3-K27 demethylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0071558 histone demethylase activity (H3-K27 specific) IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction






 

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