ENSG00000153147


Homo sapiens

Features
Gene ID: ENSG00000153147
  
Biological name :SMARCA5
  
Synonyms : O60264 / SMARCA5 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q31.21
Gene start: 143513463
Gene end: 143557486
  
Corresponding Affymetrix probe sets: 202303_x_at (Human Genome U133 Plus 2.0 Array)   213251_at (Human Genome U133 Plus 2.0 Array)   213859_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000283131
NCBI entrez gene - 8467     See in Manteia.
OMIM - 603375
RefSeq - NM_003601
RefSeq Peptide - NP_003592
swissprot - O60264
Ensembl - ENSG00000153147
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMARCA5ENSGALG00000009913Gallus gallus
 Q91ZW3ENSMUSG00000031715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P28370 / SMARCA1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1ENSG0000010203880
CHD1L / Q86WJ1 / chromodomain helicase DNA binding protein 1 likeENSG0000013177827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001005  SANT/Myb domain
 IPR001650  Helicase, C-terminal
 IPR009057  Homeobox-like domain superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR015194  ISWI, HAND domain
 IPR015195  SLIDE domain
 IPR017884  SANT domain
 IPR020838  DBINO domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029915  ISWI family
 IPR036306  ISWI, HAND domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006333 chromatin assembly or disassembly IEA
 biological_processGO:0006334 nucleosome assembly IDA
 biological_processGO:0006338 chromatin remodeling TAS
 biological_processGO:0006352 DNA-templated transcription, initiation IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0016584 nucleosome positioning IDA
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0043044 ATP-dependent chromatin remodeling IMP
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005677 chromatin silencing complex IEA
 cellular_componentGO:0016589 NURF complex IDA
 cellular_componentGO:0031010 ISWI-type complex IEA
 cellular_componentGO:0031213 RSF complex IPI
 cellular_componentGO:0043596 nuclear replication fork IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0004386 helicase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0031491 nucleosome binding IEA
 molecular_functionGO:0042393 histone binding IDA


Pathways (from Reactome)
Pathway description
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Deposition of new CENPA-containing nucleosomes at the centromere


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115163 CENPA / P49450 / centromere protein A  / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / reaction
 ENSG00000048649 RSF1 / Q96T23 / remodeling and spacing factor 1  / complex
 ENSG00000009954 BAZ1B / Q9UIG0 / bromodomain adjacent to zinc finger domain 1B  / complex
 ENSG00000137812 KNL1 / Q8NG31 / kinetochore scaffold 1  / complex
 ENSG00000076108 BAZ2A / Q9UIF9 / bromodomain adjacent to zinc finger domain 2A  / complex






 

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