ENSG00000115163


Homo sapiens

Features
Gene ID: ENSG00000115163
  
Biological name :CENPA
  
Synonyms : CENPA / centromere protein A / P49450
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p23.3
Gene start: 26764289
Gene end: 26801067
  
Corresponding Affymetrix probe sets: 204962_s_at (Human Genome U133 Plus 2.0 Array)   210821_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000336868
Ensembl peptide - ENSP00000233505
Ensembl peptide - ENSP00000404963
NCBI entrez gene - 1058     See in Manteia.
OMIM - 117139
RefSeq - NM_001809
RefSeq - NM_001042426
RefSeq Peptide - NP_001035891
RefSeq Peptide - NP_001800
swissprot - P49450
swissprot - F8WD88
Ensembl - ENSG00000115163
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CENPAENSGALG00000037735Gallus gallus
 CenpaENSMUSG00000029177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000164  Histone H3/CENP-A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0000281 mitotic cytokinesis IMP
 biological_processGO:0006334 nucleosome assembly IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051382 kinetochore assembly IDA
 biological_processGO:0071459 protein localization to chromosome, centromeric region IDA
 cellular_componentGO:0000775 chromosome, centromeric region TAS
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000778 condensed nuclear chromosome kinetochore IDA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IDA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000788 nuclear nucleosome IDA
 cellular_componentGO:0000939 condensed chromosome inner kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031618 nuclear pericentric heterochromatin IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031492 nucleosomal DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115163 CENPA / P49450 / centromere protein A  / complex
 ENSG00000104147 OIP5 / O43482 / Opa interacting protein 5  / complex
 ENSG00000159055 MIS18A / Q9NYP9 / MIS18 kinetochore protein A  / complex
 ENSG00000129534 Q6P0N0 / MIS18BP1 / MIS18 binding protein 1  / complex
 ENSG00000153147 O60264 / SMARCA5 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5  / complex
 ENSG00000048649 RSF1 / Q96T23 / remodeling and spacing factor 1  / complex
 ENSG00000137812 KNL1 / Q8NG31 / kinetochore scaffold 1  / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex






 

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