ENSMUSG00000029177


Mus musculus

Features
Gene ID: ENSMUSG00000029177
  
Biological name :Cenpa
  
Synonyms : Cenpa / Histone H3-like centromeric protein A / O35216
  
Possible biological names infered from orthology : centromere protein A / P49450
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 30666777
Gene end: 30674830
  
Corresponding Affymetrix probe sets: 10520521 (MoGene1.0st)   1441864_x_at (Mouse Genome 430 2.0 Array)   1444416_at (Mouse Genome 430 2.0 Array)   1450842_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119363
Ensembl peptide - ENSMUSP00000122831
Ensembl peptide - ENSMUSP00000143575
Ensembl peptide - ENSMUSP00000142917
Ensembl peptide - ENSMUSP00000142915
Ensembl peptide - ENSMUSP00000123493
Ensembl peptide - ENSMUSP00000031073
NCBI entrez gene - 12615     See in Manteia.
MGI - MGI:88375
RefSeq - XM_011240699
RefSeq - NM_001302129
RefSeq - NM_001302130
RefSeq - NM_001302131
RefSeq - NM_001302132
RefSeq - NM_007681
RefSeq Peptide - NP_001289060
RefSeq Peptide - NP_031707
RefSeq Peptide - NP_001289058
RefSeq Peptide - NP_001289059
RefSeq Peptide - NP_001289061
swissprot - A0A0G2JEV0
swissprot - D6RCV6
swissprot - A0A0G2JGI2
swissprot - O35216
swissprot - D6RJ71
swissprot - A0A0G2JEV2
Ensembl - ENSMUSG00000029177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CENPAENSGALG00000037735Gallus gallus
 CENPAENSG00000115163Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000164  Histone H3/CENP-A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0006334 nucleosome assembly IBA
 biological_processGO:0051382 kinetochore assembly IEA
 biological_processGO:0071459 protein localization to chromosome, centromeric region IEA
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000778 condensed nuclear chromosome kinetochore IEA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IEA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000788 nuclear nucleosome IEA
 cellular_componentGO:0000939 condensed chromosome inner kinetochore IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0031618 nuclear pericentric heterochromatin IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0031492 nucleosomal DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005028 abnormal trophectoderm "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Serpinf1tm1Craw/Serpinf1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029177 Cenpa / O35216 / Histone H3-like centromeric protein A / P49450* / centromere protein A*  / complex
 ENSMUSG00000027326 Knl1 / Q66JQ7 / Kinetochore scaffold 1 / Q8NG31*  / complex
 ENSMUSG00000031715 Q91ZW3 / Smarca5 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 / O60264*  / complex
 ENSMUSG00000047534 Q80WQ8 / Mis18bp1 / Mis18-binding protein 1 / Q6P0N0*  / complex
 ENSMUSG00000035623 Rsf1 / remodeling and spacing factor 1 / Q96T23*  / complex
 ENSMUSG00000022978 Mis18a / Q9CZJ6 / Protein Mis18-alpha / Q9NYP9* / MIS18 kinetochore protein A*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000072980 Oip5 / A2AQ14 / Protein Mis18-beta / O43482* / Opa interacting protein 5*  / complex






 

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