ENSMUSG00000022978


Mus musculus

Features
Gene ID: ENSMUSG00000022978
  
Biological name :Mis18a
  
Synonyms : Mis18a / Protein Mis18-alpha / Q9CZJ6
  
Possible biological names infered from orthology : MIS18 kinetochore protein A / Q9NYP9
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.3
Gene start: 90719312
Gene end: 90727404
  
Corresponding Affymetrix probe sets: 10440794 (MoGene1.0st)   1428483_a_at (Mouse Genome 430 2.0 Array)   1453314_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097150
NCBI entrez gene - 66578     See in Manteia.
MGI - MGI:1913828
RefSeq - NM_025642
RefSeq Peptide - NP_079918
swissprot - Q9CZJ6
Ensembl - ENSMUSG00000022978
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mis18aENSDARG00000035333Danio rerio
 MIS18AENSGALG00000015884Gallus gallus
 MIS18AENSG00000159055Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004910  Yippee/Mis18/Cereblon
 IPR034752  Mis18 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0034080 CENP-A containing nucleosome assembly IMP
 biological_processGO:0044030 regulation of DNA methylation IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0000775 chromosome, centromeric region IDA
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Deposition of new CENPA-containing nucleosomes at the centromere


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

Allelic Composition: Mis18atm1.1Kiik/Mis18atm1.2Kiik
Genetic Background: B6(129S)-Mis18atm1.1Kiik/Mis18atm1.2Kiik

 MP:0004965 inner cell mass degeneration 
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0009850 embryonic lethality between implantation and placentation "death anytime after implantation but before placentation (Mus: E4.5 to less than E9)" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Mis18atm1.1Kiik/Mis18atm1.2Kiik
Genetic Background: B6(129S)-Mis18atm1.1Kiik/Mis18atm1.2Kiik

 MP:0012113 decreased inner cell mass proliferation 
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Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000072980 Oip5 / A2AQ14 / Protein Mis18-beta / O43482* / Opa interacting protein 5*  / complex
 ENSMUSG00000027326 Knl1 / Q66JQ7 / Kinetochore scaffold 1 / Q8NG31*  / reaction / complex
 ENSMUSG00000047534 Q80WQ8 / Mis18bp1 / Mis18-binding protein 1 / Q6P0N0*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000029177 Cenpa / O35216 / Histone H3-like centromeric protein A / P49450* / centromere protein A*  / complex






 

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