ENSMUSG00000027326


Mus musculus

Features
Gene ID: ENSMUSG00000027326
  
Biological name :Knl1
  
Synonyms : Kinetochore scaffold 1 / Knl1 / Q66JQ7
  
Possible biological names infered from orthology : Q8NG31
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 119047119
Gene end: 119105501
  
Corresponding Affymetrix probe sets: 10474875 (MoGene1.0st)   1430193_at (Mouse Genome 430 2.0 Array)   1438833_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028802
Ensembl peptide - ENSMUSP00000120905
Ensembl peptide - ENSMUSP00000118646
Ensembl peptide - ENSMUSP00000097140
Ensembl peptide - ENSMUSP00000028799
NCBI entrez gene - 76464     See in Manteia.
MGI - MGI:1923714
RefSeq - XM_006500377
RefSeq - NM_029617
RefSeq - XM_006500376
RefSeq Peptide - NP_083893
swissprot - A3KGI6
swissprot - Q66JQ7
swissprot - A3KGI3
swissprot - A3KGI5
Ensembl - ENSMUSG00000027326
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 knl1ENSDARG00000070239Danio rerio
 ENSGALG00000045185Gallus gallus
 KNL1ENSG00000137812Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR037388  Kinetochore scaffold 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0008608 attachment of spindle microtubules to kinetochore IEA
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 biological_processGO:0034501 protein localization to kinetochore IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1m1Anu/Rag1m1Anu
Genetic Background: C57BL/6NCrlAnu-Rag1m1Anu

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Lmx1atm1Ics/Lmx1atm1Ics,Lmx1btm1Rjo/Lmx1b+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029177 Cenpa / O35216 / Histone H3-like centromeric protein A / P49450* / centromere protein A*  / complex
 ENSMUSG00000074476 Spc24 / Q9D083 / Kinetochore protein Spc24 / Q8NBT2* / SPC24, NDC80 kinetochore complex component*  / complex
 ENSMUSG00000028066 Pmf1 / Q9CPV5 / Polyamine-modulated factor 1 / Q6P1K2*  / complex
 ENSMUSG00000027635 Dsn1 / Q9CYC5 / Kinetochore-associated / Q9H410* / DSN1 homolog, MIS12 kinetochore complex component*  / complex
 ENSMUSG00000026683 Nuf2 / Q99P69 / Mus musculus NUF2, NDC80 kinetochore complex component (Nuf2), transcript variant 2, mRNA. / Q9BZD4* / NUF2, NDC80 kinetochore complex component*  / complex
 ENSMUSG00000005233 Spc25 / Q3UA16 / Kinetochore protein Spc25 / Q9HBM1* / SPC25, NDC80 kinetochore complex component*  / complex
 ENSMUSG00000062510 Nsl1 / NSL1, MIS12 kinetochore complex component / Q96IY1*  / complex
 ENSMUSG00000024056 Ndc80 / Q9D0F1 / Kinetochore / O14777* / NDC80, kinetochore complex component*  / complex
 ENSMUSG00000040599 Mis12 / Q9CY25 / MIS12, kinetochore complex component / Q9H081*  / complex
 ENSMUSG00000031715 Q91ZW3 / Smarca5 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 / O60264*  / complex
 ENSMUSG00000047534 Q80WQ8 / Mis18bp1 / Mis18-binding protein 1 / Q6P0N0*  / complex / reaction
 ENSMUSG00000035623 Rsf1 / remodeling and spacing factor 1 / Q96T23*  / complex
 ENSMUSG00000022978 Mis18a / Q9CZJ6 / Protein Mis18-alpha / Q9NYP9* / MIS18 kinetochore protein A*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000072980 Oip5 / A2AQ14 / Protein Mis18-beta / O43482* / Opa interacting protein 5*  / reaction / complex






 

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