ENSMUSG00000040599


Mus musculus

Features
Gene ID: ENSMUSG00000040599
  
Biological name :Mis12
  
Synonyms : Mis12 / MIS12, kinetochore complex component / Q9CY25
  
Possible biological names infered from orthology : Q9H081
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B4
Gene start: 71019611
Gene end: 71027371
  
Corresponding Affymetrix probe sets: 10378024 (MoGene1.0st)   1424717_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116762
Ensembl peptide - ENSMUSP00000127782
Ensembl peptide - ENSMUSP00000123291
Ensembl peptide - ENSMUSP00000121057
Ensembl peptide - ENSMUSP00000039500
Ensembl peptide - ENSMUSP00000115256
NCBI entrez gene - 67139     See in Manteia.
MGI - MGI:1914389
RefSeq - XM_006533969
RefSeq - NM_025993
RefSeq - XM_006533968
RefSeq Peptide - NP_080269
swissprot - A3QK66
swissprot - Q9CY25
swissprot - A0A0G2JDA2
swissprot - A3QK65
Ensembl - ENSMUSG00000040599
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mis12ENSDARG00000026454Danio rerio
 MIS12ENSGALG00000001632Gallus gallus
 MIS12ENSG00000167842Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008685  Centromere protein Mis12


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IBA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0034501 protein localization to kinetochore IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore IEA
 biological_processGO:0051382 kinetochore assembly IEA
 cellular_componentGO:0000444 MIS12/MIND type complex IEA
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore ISO
 cellular_componentGO:0000818 nuclear MIS12/MIND complex IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027326 Knl1 / Q66JQ7 / Kinetochore scaffold 1 / Q8NG31*  / complex
 ENSMUSG00000074476 Spc24 / Q9D083 / Kinetochore protein Spc24 / Q8NBT2* / SPC24, NDC80 kinetochore complex component*  / complex
 ENSMUSG00000026683 Nuf2 / Q99P69 / Mus musculus NUF2, NDC80 kinetochore complex component (Nuf2), transcript variant 2, mRNA. / Q9BZD4* / NUF2, NDC80 kinetochore complex component*  / complex
 ENSMUSG00000005233 Spc25 / Q3UA16 / Kinetochore protein Spc25 / Q9HBM1* / SPC25, NDC80 kinetochore complex component*  / complex
 ENSMUSG00000024056 Ndc80 / Q9D0F1 / Kinetochore / O14777* / NDC80, kinetochore complex component*  / complex
 ENSMUSG00000028066 Pmf1 / Q9CPV5 / Polyamine-modulated factor 1 / Q6P1K2*  / complex
 ENSMUSG00000062510 Nsl1 / NSL1, MIS12 kinetochore complex component / Q96IY1*  / complex
 ENSMUSG00000027635 Dsn1 / Q9CYC5 / Kinetochore-associated / Q9H410* / DSN1 homolog, MIS12 kinetochore complex component*  / complex






 

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