ENSMUSG00000024056


Mus musculus

Features
Gene ID: ENSMUSG00000024056
  
Biological name :Ndc80
  
Synonyms : Kinetochore / Ndc80 / Q9D0F1
  
Possible biological names infered from orthology : NDC80, kinetochore complex component / O14777
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E1.3
Gene start: 71496100
Gene end: 71526857
  
Corresponding Affymetrix probe sets: 10452709 (MoGene1.0st)   1417445_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024851
NCBI entrez gene - 67052     See in Manteia.
MGI - MGI:1914302
RefSeq - NM_023294
RefSeq Peptide - NP_075783
swissprot - Q9D0F1
Ensembl - ENSMUSG00000024056
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndc80ENSDARG00000071694Danio rerio
 NDC80ENSGALG00000014801Gallus gallus
 NDC80ENSG00000080986Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005550  Kinetochore protein Ndc80


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation ISO
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0008608 attachment of spindle microtubules to kinetochore IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051310 metaphase plate congression IEA
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore IEA
 biological_processGO:0051383 kinetochore organization IEA
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IEA
 biological_processGO:1905342 positive regulation of protein localization to kinetochore IEA
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore ISO
 cellular_componentGO:0000778 condensed nuclear chromosome kinetochore IBA
 cellular_componentGO:0000942 condensed nuclear chromosome outer kinetochore IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0031262 Ndc80 complex IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005233 Spc25 / Q3UA16 / Kinetochore protein Spc25 / Q9HBM1* / SPC25, NDC80 kinetochore complex component*  / complex
 ENSMUSG00000026683 Nuf2 / Q99P69 / Mus musculus NUF2, NDC80 kinetochore complex component (Nuf2), transcript variant 2, mRNA. / Q9BZD4* / NUF2, NDC80 kinetochore complex component*  / complex
 ENSMUSG00000027326 Knl1 / Q66JQ7 / Kinetochore scaffold 1 / Q8NG31*  / complex
 ENSMUSG00000040599 Mis12 / Q9CY25 / MIS12, kinetochore complex component / Q9H081*  / complex
 ENSMUSG00000028066 Pmf1 / Q9CPV5 / Polyamine-modulated factor 1 / Q6P1K2*  / complex
 ENSMUSG00000062510 Nsl1 / NSL1, MIS12 kinetochore complex component / Q96IY1*  / complex
 ENSMUSG00000074476 Spc24 / Q9D083 / Kinetochore protein Spc24 / Q8NBT2* / SPC24, NDC80 kinetochore complex component*  / complex
 ENSMUSG00000027635 Dsn1 / Q9CYC5 / Kinetochore-associated / Q9H410* / DSN1 homolog, MIS12 kinetochore complex component*  / complex






 

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