ENSG00000080986


Homo sapiens

Features
Gene ID: ENSG00000080986
  
Biological name :NDC80
  
Synonyms : NDC80 / NDC80, kinetochore complex component / O14777
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: p11.32
Gene start: 2571511
Gene end: 2616635
  
Corresponding Affymetrix probe sets: 204162_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000458236
Ensembl peptide - ENSP00000476919
Ensembl peptide - ENSP00000461227
Ensembl peptide - ENSP00000261597
NCBI entrez gene - 10403     See in Manteia.
OMIM - 607272
RefSeq - NM_006101
RefSeq Peptide - NP_006092
swissprot - O14777
swissprot - A8K031
swissprot - V9GYM9
swissprot - I3L0P0
swissprot - I3L4G3
Ensembl - ENSG00000080986
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndc80ENSDARG00000071694Danio rerio
 NDC80ENSGALG00000014801Gallus gallus
 Ndc80ENSMUSG00000024056Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005550  Kinetochore protein Ndc80


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation TAS
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization IMP
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0008608 attachment of spindle microtubules to kinetochore IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051310 metaphase plate congression IMP
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore IMP
 biological_processGO:0051383 kinetochore organization IMP
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
 biological_processGO:1905342 positive regulation of protein localization to kinetochore IMP
 cellular_componentGO:0000775 chromosome, centromeric region TAS
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000942 condensed nuclear chromosome outer kinetochore IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031262 Ndc80 complex IDA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000152253 SPC25 / Q9HBM1 / SPC25, NDC80 kinetochore complex component  / complex
 ENSG00000143228 NUF2 / Q9BZD4 / NUF2, NDC80 kinetochore complex component  / complex
 ENSG00000137812 KNL1 / Q8NG31 / kinetochore scaffold 1  / complex
 ENSG00000160783 PMF1 / Q6P1K2 / polyamine modulated factor 1  / complex
 ENSG00000149636 DSN1 / Q9H410 / DSN1 homolog, MIS12 kinetochore complex component  / complex
 ENSG00000117697 NSL1 / Q96IY1 / NSL1, MIS12 kinetochore complex component  / complex
 ENSG00000167842 MIS12 / Q9H081 / MIS12, kinetochore complex component  / complex
 ENSG00000161888 SPC24 / Q8NBT2 / SPC24, NDC80 kinetochore complex component  / complex






 

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