ENSG00000152253


Homo sapiens

Features
Gene ID: ENSG00000152253
  
Biological name :SPC25
  
Synonyms : Q9HBM1 / SPC25 / SPC25, NDC80 kinetochore complex component
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q31.1
Gene start: 168834132
Gene end: 168913371
  
Corresponding Affymetrix probe sets: 209891_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000282074
Ensembl peptide - ENSP00000393322
NCBI entrez gene - 57405     See in Manteia.
OMIM - 609395
RefSeq - NM_020675
RefSeq - XM_011511516
RefSeq Peptide - NP_065726
swissprot - C9JW94
swissprot - Q9HBM1
Ensembl - ENSG00000152253
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spc25ENSDARG00000078433Danio rerio
 SPC25ENSGALG00000010900Gallus gallus
 Spc25ENSMUSG00000005233Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013255  Chromosome segregation protein Spc25


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization IMP
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0031262 Ndc80 complex IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000080986 NDC80 / O14777 / NDC80, kinetochore complex component  / complex
 ENSG00000143228 NUF2 / Q9BZD4 / NUF2, NDC80 kinetochore complex component  / complex
 ENSG00000137812 KNL1 / Q8NG31 / kinetochore scaffold 1  / complex
 ENSG00000160783 PMF1 / Q6P1K2 / polyamine modulated factor 1  / complex
 ENSG00000149636 DSN1 / Q9H410 / DSN1 homolog, MIS12 kinetochore complex component  / complex
 ENSG00000117697 NSL1 / Q96IY1 / NSL1, MIS12 kinetochore complex component  / complex
 ENSG00000167842 MIS12 / Q9H081 / MIS12, kinetochore complex component  / complex
 ENSG00000161888 SPC24 / Q8NBT2 / SPC24, NDC80 kinetochore complex component  / complex






 

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